Anti-KLK14 Antibody (CAB10767)
- SKU:
- CAB10767
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KLK14 Antibody |
| 抗体コード: | CAB10767 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 41-267 of human KLK14 (NP_071329.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse stomach |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 41-267 of human KLK14 (NP_071329.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IIGG HTCT RSSQ PWQA ALLA GPRR RFLC GGAL LSGQ WVIT AAHC GRPI LQVA LGKH NLRR WEAT QQVL RVVR QVTH PNYN SRTH DNDL MLLQ LQQP ARIG RAVR PIEV TQAC ASPG TSCR VSGW GTIS SPIA RYPA SLQC VNIN ISPD EVCQ KAYP RTIT PGMV CAGV PQGG KDSC QGDS GGPL VCRG QLQG LVSW GMER CALP GYPG VYTN LCKY RSWI EETM RDK |
| 遺伝子ID: | 43847 |
| Uniprot: | Q9P0G3 |
| セルラーロケーション: | Secreted, extracellular space |
| 計算された分子量: | 29kDa |
| 観察された分子量: | 29kDa |
| 同義語: | KLK14, KLK-L6 |
| バックグラウンド: | This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | KLK14: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. Belongs to the peptidase S1 family. Kallikrein subfamily. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Protease; EC 3.4.21.-; Secreted Chromosomal Location of Human Ortholog: 19q13.3-q13.4 Cellular Component: extracellular space Molecular Function:serine-type endopeptidase activity Biological Process: epidermis morphogenesis; fertilization; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; proteolysis |
| NCBI Summary: | This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
| UniProt Code: | Q9P0G3 |
| NCBI GenInfo Identifier: | 251757292 |
| NCBI Gene ID: | 43847 |
| NCBI Accession: | Q9P0G3.2 |
| UniProt Secondary Accession: | Q9P0G3,Q1RMZ2, Q6B089, A7UNK5, |
| UniProt Related Accession: | Q9P0G3 |
| Molecular Weight: | 29,122 Da |
| NCBI Full Name: | Kallikrein-14 |
| NCBI Synonym Full Names: | kallikrein related peptidase 14 |
| NCBI Official Symbol: | KLK14 |
| NCBI Official Synonym Symbols: | KLK-L6 |
| NCBI Protein Information: | kallikrein-14 |
| UniProt Protein Name: | Kallikrein-14 |
| UniProt Synonym Protein Names: | Kallikrein-like protein 6; KLK-L6 |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK14 |
| UniProt Entry Name: | KLK14_HUMAN |
 | Western blot analysis of extracts of mouse stomach, using KLK14 antibody (CAB10767) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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