Anti-KLK10 Antibody (CAB6398)
- SKU:
- CAB6398
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-KLK10 Antibody |
| 抗体コード: | CAB6398 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-276 of human KLK10 (NP_001070968.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Mouse brain, Mouse heart, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-276 of human KLK10 (NP_001070968.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LLPQ NDTR LDPE AYGS PCAR GSQP WQVS LFNG LSFH CAGV LVDQ SWVL TAAH CGNK PLWA RVGD DHLL LLQG EQLR RTTR SVVH PKYH QGSG PILP RRTD EHDL MLLK LARP VVLG PRVR ALQL PYRC AQPG DQCQ VAGW GTTA ARRV KYNK GLTC SSIT ILSP KECE VFYP GVVT NNMI CAGL DRGQ DPCQ SDSG GPLV CDET LQGI LSWG VYPC GSAQ HPAV YTQI CKYM SWIN KVIR SN |
| 遺伝子ID: | 5655 |
| Uniprot: | O43240 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 30kDa |
| 観察された分子量: | 30kDa |
| 同義語: | KLK10, NES1, PRSSL1 |
| バックグラウンド: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. |
| UniProt Protein Function: | KLK10: Has a tumor-suppressor role for NES1 in breast and prostate cancer. Belongs to the peptidase S1 family. Kallikrein subfamily. |
| UniProt Protein Details: | Protein type:Secreted; Tumor suppressor; Protease; Secreted, signal peptide; EC 3.4.21.- Chromosomal Location of Human Ortholog: 19q13 Molecular Function:serine-type peptidase activity |
| NCBI Summary: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43240 |
| NCBI GenInfo Identifier: | 317373432 |
| NCBI Gene ID: | 5655 |
| NCBI Accession: | O43240.3 |
| UniProt Secondary Accession: | O43240,Q53YL3, Q99920, Q9GZW9, A6NC12, |
| UniProt Related Accession: | O43240 |
| Molecular Weight: | 30,170 Da |
| NCBI Full Name: | Kallikrein-10 |
| NCBI Synonym Full Names: | kallikrein related peptidase 10 |
| NCBI Official Symbol: | KLK10 |
| NCBI Official Synonym Symbols: | NES1; PRSSL1 |
| NCBI Protein Information: | kallikrein-10 |
| UniProt Protein Name: | Kallikrein-10 |
| UniProt Synonym Protein Names: | Normal epithelial cell-specific 1; Protease serine-like 1 |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | KLK10 |
| UniProt Entry Name: | KLK10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KLK10 antibody (CAB6398) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human breast using KLK10 Antibody (CAB6398) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of MCF7 cells using KLK10 antibody (CAB6398). Blue: DAPI for nuclear staining. |
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