Anti-KLF5 Antibody (CAB2989)
- SKU:
- CAB2989
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-KLF5 Antibody |
抗体コード: | CAB2989 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human KLF5 (NP_001721.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:200 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | U-87MG, HeLa, A-549, HT-1080, HT-29 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human KLF5 (NP_001721.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MATR VLSM SARL GPVP QPPA PQDE PVFA QLKP VLGA ANPA RDAA LFPG EELK HAHH RPQA QPAP AQAP QPAQ PPAT GPRL PPED LVQT RCEM EKYL TPQL PPVP IIPE HKKY RRDS ASVV DQFF TDTE GLPY SINM NVFL PDIT HLRT GLYK SQRP CVTH IKTE PVAI FSHQ SETT APPP APTQ ALPE FTSI FSSH QTAA PEVN NIFI KQEL PTPD LHLS VPTQ QGHL YQLL NTPD LDMP SSTN QTAA MD |
遺伝子ID: | 688 |
Uniprot: | Q13887 |
セルラーロケーション: | Nucleus |
計算された分子量: | 18kDa/33kDa/41kDa/50kDa |
観察された分子量: | 55kDa |
同義語: | KLF5, BTEB2, CKLF, IKLF |
バックグラウンド: | This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | KLF5: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family. |
UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 13q22.1 Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; cytoplasm; plasma membrane Molecular Function:protein binding; metal ion binding Biological Process: transcription from RNA polymerase II promoter; microvillus biogenesis; positive regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of microvillus biogenesis |
NCBI Summary: | This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] |
UniProt Code: | Q13887 |
NCBI GenInfo Identifier: | 12644412 |
NCBI Gene ID: | 688 |
NCBI Accession: | Q13887.2 |
UniProt Secondary Accession: | Q13887,Q9UHP8, L0R3U5, L0R4T9, |
UniProt Related Accession: | Q13887 |
Molecular Weight: | 457 |
NCBI Full Name: | Krueppel-like factor 5 |
NCBI Synonym Full Names: | Kruppel-like factor 5 (intestinal) |
NCBI Official Symbol: | KLF5 |
NCBI Official Synonym Symbols: | CKLF; IKLF; BTEB2 |
NCBI Protein Information: | Krueppel-like factor 5; Klf5C isoform; BTE-binding protein 2; GC box binding protein 2; colon kruppel-like factor; colon krueppel-like factor; transcription factor BTEB2; intestinal-enriched kruppel-like factor; intestinal-enriched krueppel-like factor; b |
UniProt Protein Name: | Krueppel-like factor 5 |
UniProt Synonym Protein Names: | Basic transcription element-binding protein 2; BTE-binding protein 2; Colon krueppel-like factor; GC-box-binding protein 2; Intestinal-enriched krueppel-like factor; Transcription factor BTEB2 |
Protein Family: | Krueppel-like factor |
UniProt Gene Name: | KLF5 |
UniProt Entry Name: | KLF5_HUMAN |
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