Anti-KLF10 Antibody (CAB13180)
- SKU:
- CAB13180
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KLF10 Antibody |
| 抗体コード: | CAB13180 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 161-365 of human KLF10 (NP_001027453.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse kidney, Mouse skeletal muscle, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 161-365 of human KLF10 (NP_001027453.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MKAA SILN YQNN SFRR RTHL NVEA ARKN IPCA AVSP NRSK CERN TVAD VDEK ASAA LYDF SVPS SETV ICRS QPAP VSPQ QKSV LVSP PAVS AGGV PPMP VICQ MVPL PANN PVVT TVVP STPP SQPP AVCP PVVF MGTQ VPKG AVMF VVPQ PVVQ SSKP PVVS PNGT RLSP IAPA PGFS PSAA KVTP QIDS SRIR SHIC SHPG C |
| 遺伝子ID: | 7071 |
| Uniprot: | Q13118 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 10kDa/13kDa/51kDa/52kDa |
| 観察された分子量: | 56kDa |
| 同義語: | KLF10, EGR-alpha, EGRA, TIEG, TIEG1 |
| バックグラウンド: | This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | KLF10: Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; C2H2-type zinc finger protein; DNA-binding Chromosomal Location of Human Ortholog: 8q22.2 Cellular Component: nucleus Molecular Function:protein binding; metal ion binding; transcription factor activity Biological Process: circadian rhythm; transcription, DNA-dependent; positive regulation of osteoclast differentiation; somatic stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; cellular response to starvation; regulation of circadian rhythm; bone mineralization; cell proliferation; negative regulation of cell proliferation; cell-cell signaling; transforming growth factor beta receptor signaling pathway; negative regulation of transcription, DNA-dependent; skeletal development |
| NCBI Summary: | This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q13118 |
| NCBI GenInfo Identifier: | 11387050 |
| NCBI Gene ID: | 7071 |
| NCBI Accession: | Q13118.1 |
| UniProt Secondary Accession: | Q13118,O75411, Q503B2, A8MVH0, B2R794, L0R4P6, L0R679 |
| UniProt Related Accession: | Q13118 |
| Molecular Weight: | 480 |
| NCBI Full Name: | Krueppel-like factor 10 |
| NCBI Synonym Full Names: | Kruppel-like factor 10 |
| NCBI Official Symbol: | KLF10 |
| NCBI Official Synonym Symbols: | EGRA; TIEG; TIEG1; EGR-alpha |
| NCBI Protein Information: | Krueppel-like factor 10; early growth response-alpha; zinc finger transcription factor TIEG; TGFB-inducible early growth response protein 1; transforming growth factor-beta-inducible early growth response protein 1 |
| UniProt Protein Name: | Krueppel-like factor 10 |
| UniProt Synonym Protein Names: | EGR-alpha; Transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1 |
| Protein Family: | Krueppel-like factor |
| UniProt Gene Name: | KLF10 |
| UniProt Entry Name: | KLF10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KLF10 antibody (CAB13180) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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