Anti-KIF21A Antibody (CAB16548)
- SKU:
- CAB16548
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KIF21A Antibody |
| 抗体コード: | CAB16548 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1070-1270 of human KIF21A (NP_001166935.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, |
| ポジティブサンプル: | U-87MG, LO2, HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1070-1270 of human KIF21A (NP_001166935.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KQTE ITSA TQNQ LLFH MLKE KAEL NPEL DALL GHAL QDLD SVPL ENVE DSTD EDAP LNSP GSEG STLS SDLM KLCG EVKP KNKA RRRT TTQM ELLY ADSS ELAS DTST GDAS LPGP LTPV AEGQ EIGM NTET SGTS AREK ELSP PPGL PSKI GSIS RQSS LSEK KIPE PSPV TRRK AYEK AEKS KAKE QKHS DSGT SEAS L |
| 遺伝子ID: | 55605 |
| Uniprot: | Q7Z4S6 |
| セルラーロケーション: | Cytoplasm, cytoskeleton |
| 計算された分子量: | 180kDa/182kDa/185kDa/187kDa |
| 観察された分子量: | 187kDa |
| 同義語: | KIF21A, CFEOM1, FEOM1, FEOM3A |
| バックグラウンド: | This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | KIF21A: Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. Defects in KIF21A are a cause of congenital fibrosis of extraocular muscles type 1 (CFEOM1). CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM1 individuals show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei. Belongs to the kinesin-like protein family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Microtubule-binding; Motor Chromosomal Location of Human Ortholog: 12q12 Cellular Component: microtubule; kinesin complex; cytoplasm Molecular Function:protein binding; microtubule binding; ATPase activity; microtubule motor activity; ATP binding Biological Process: metabolic process; microtubule-based movement Disease: Fibrosis Of Extraocular Muscles, Congenital, 1 |
| NCBI Summary: | This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010] |
| UniProt Code: | Q7Z4S6 |
| NCBI GenInfo Identifier: | 38569484 |
| NCBI Gene ID: | 55605 |
| NCBI Accession: | NP_060111 |
| UniProt Related Accession: | Q7Z4S6 |
| Molecular Weight: | 186kDa |
| NCBI Full Name: | kinesin-like protein KIF21A isoform 2 |
| NCBI Synonym Full Names: | kinesin family member 21A |
| NCBI Official Symbol: | KIF21A |
| NCBI Official Synonym Symbols: | FEOM1; CFEOM1; FEOM3A |
| NCBI Protein Information: | kinesin-like protein KIF21A |
| UniProt Protein Name: | Kinesin-like protein KIF21A |
| UniProt Synonym Protein Names: | Kinesin-like protein KIF2; Renal carcinoma antigen NY-REN-62 |
| Protein Family: | Kinesin-like protein |
| UniProt Gene Name: | KIF21A |
| UniProt Entry Name: | KI21A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KIF21A antibody (CAB16548) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
 | Immunofluorescence analysis of L929 cells using KIF21A Rabbit pAb (CAB16548) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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