Anti-KIF13A Antibody (CAB15880)
- SKU:
- CAB15880
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-KIF13A Antibody |
| 抗体コード: | CAB15880 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1300-1600 of human KIF13A (NP_001099036.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | LO2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1300-1600 of human KIF13A (NP_001099036.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SCGV TYEI VSNI PKAT EEIE DRET LALL AARS ENEG TSDG ETYI EKYT RGVL QVEN ILSL ERLR QAVT VKEA LSTK ARHI RRSL STPN VHNV SSSR PDLS GFDE DDKG WPEN QLDM SDYS SSYQ DVAC YGTL PRDS PRRN KEGC TSET PHAL TVSP FKAF SPQP PKFF KPLM PVKE EHKK RIAL EARP LLSQ EDSE EEEN ELEA INRK LISS QPYV PVEF ADFS VYNA SLEN REWF SSKV DLSN SRVL EKEV SRSP TTSS ITSG YFSH SASN ATLS DMVV PSSD SSDQ LAIQ TKDA DSTE H |
| 遺伝子ID: | 63971 |
| Uniprot: | Q9H1H9 |
| セルラーロケーション: | Cytoplasm, Endosome membrane, Golgi apparatus membrane, Midbody, centrosome, cytoskeleton, microtubule organizing center |
| 計算された分子量: | 7kDa/196kDa/197kDa/198kDa/202kDa |
| 観察された分子量: | 250kDa |
| 同義語: | KIF13A, RBKIN, bA500C11.2 |
| バックグラウンド: | This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | KIF13A: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR- containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. Belongs to the kinesin-like protein family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Microtubule-binding; Motor Chromosomal Location of Human Ortholog: 6p23 Cellular Component: Golgi membrane; kinesin complex; microtubule; centrosome; trans-Golgi network membrane; endosome membrane; midbody Molecular Function:protein binding; microtubule binding; ATPase activity; microtubule motor activity; ATP binding Biological Process: intracellular protein transport; melanosome organization and biogenesis; metabolic process; Golgi to plasma membrane protein transport; cytokinesis; endosome to lysosome transport; microtubule-based movement |
| NCBI Summary: | This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9H1H9 |
| NCBI GenInfo Identifier: | 157738625 |
| NCBI Gene ID: | 63971 |
| NCBI Accession: | NP_001099036.1 |
| UniProt Secondary Accession: | Q9H1H9,Q5THQ2, Q5THQ3, Q9H193, Q9H194, Q9H1H8, A0JP21 A0JP22, F2Z382, |
| UniProt Related Accession: | Q9H1H9 |
| Molecular Weight: | 7,726 Da |
| NCBI Full Name: | kinesin-like protein KIF13A isoform b |
| NCBI Synonym Full Names: | kinesin family member 13A |
| NCBI Official Symbol: | KIF13A |
| NCBI Official Synonym Symbols: | RBKIN; bA500C11.2 |
| NCBI Protein Information: | kinesin-like protein KIF13A |
| UniProt Protein Name: | Kinesin-like protein KIF13A |
| UniProt Synonym Protein Names: | Kinesin-like protein RBKIN |
| Protein Family: | Kinesin-like protein |
| UniProt Gene Name: | KIF13A |
| UniProt Entry Name: | KI13A_HUMAN |
 | Western blot analysis of extracts of LO2 cells, using KIF13A antibody (CAB15880) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of HeLa cells using KIF13A antibody (CAB15880) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using KIF13A antibody (CAB15880) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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