Anti-KIAA1524 Antibody (CAB12267)
- SKU:
- CAB12267
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KIAA1524 Antibody |
| 抗体コード: | CAB12267 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 681-905 of human KIAA1524 (NP_065941.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, U-87MG, MCF7, HeLa, A375, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 681-905 of human KIAA1524 (NP_065941.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EVER KNEE LSVL LKAQ QVES ERAQ SDIE HLFQ HNRK LESV AEEH EILT KSYM ELLQ RNES TEKK NKDL QITC DSLN KQIE TVKK LNES LKEQ NEKS IAQL IEKE EQRK EVQN QLVD REHK LANL HQKT KVQE EKIK TLQK ERED KEET IDIL RKEL SRTE QIRK ELSI KASS LEVQ KAQL EGRL EEKE SLVK LQQE ELNK HSHM IAMI HSLS GGKI NPET VNLS I |
| 遺伝子ID: | 57650 |
| Uniprot: | Q8TCG1 |
| セルラーロケーション: | Cytoplasm, Membrane, Single-pass membrane protein |
| 計算された分子量: | 84kDa/102kDa |
| 観察された分子量: | 102kDa |
| 同義語: | KIAA1524, CIP2A, p90 |
| バックグラウンド: |
| UniProt Protein Function: | CIP2A: an oncoprotein that inhibits PP2A in human malignancies. Like the SV40 small t antigen, inhibits the phospho-serine/-threonine phosphatase PP2A. Promotes c-Myc protein stability by inhibiting the dephosphorylation of phospho-serine 62. Expressed at low levels in most of nonmalignant tissues but at high levels in human malignancies including head and neck squamous cell carcinoma (HNSCC), colon cancer, and liver cancer. Antibodies against CIP2A are present in sera from many patients with gastric or prostate cancer. Two alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3q13.13 Cellular Component: cytoplasm; plasma membrane Molecular Function:protein binding |
| UniProt Code: | Q8TCG1 |
| NCBI GenInfo Identifier: | 147647143 |
| NCBI Gene ID: | 57650 |
| NCBI Accession: | Q8TCG1.2 |
| UniProt Secondary Accession: | Q8TCG1,Q6P4G6, Q8WVP8, Q96PI2, Q9H9C6, Q9P204, A1L4J7 B9EGC3, |
| UniProt Related Accession: | Q8TCG1 |
| Molecular Weight: | 102185 Da |
| NCBI Full Name: | Protein CIP2A |
| NCBI Synonym Full Names: | KIAA1524 |
| NCBI Official Symbol: | KIAA1524 |
| NCBI Official Synonym Symbols: | p90; CIP2A |
| NCBI Protein Information: | protein CIP2A |
| UniProt Protein Name: | Protein CIP2A |
| UniProt Synonym Protein Names: | Cancerous inhibitor of PP2A; p90 autoantigen |
| Protein Family: | Protein |
| UniProt Gene Name: | KIAA1524 |
| UniProt Entry Name: | CIP2A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KIAA1524 antibody (CAB12267) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded mouse testis using KIAA1524 antibody (CAB12267) at dilution of 1:100 (40x lens). |
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