Anti-KEL Antibody (CAB10116)
- SKU:
- CAB10116
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KEL Antibody |
| 抗体コード: | CAB10116 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-310 of human KEL (NP_000411.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:1000 |
| 反応性: | Human |
| ポジティブサンプル: | Raji, A375, K-562 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-310 of human KEL (NP_000411.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QNCG PRPC ETSV CLDL RDHY LASG NTSV APCT DFFS FACG RAKE TNNS FQEL ATKN KNRL RRIL EVQN SWHP GSGE EKAF QFYN SCMD TLAI EAAG TGPL RQVI EELG GWRI SGKW TSLN FNRT LRLL MSQY GHFP FFRA YLGP HPAS PHTP VIQI DQPE FDVP LKQD QEQK IYAQ IFRE YLTY LNQL GTLL GGDP SKVQ EHSS LSIS ITSR LFQF LRPL EQRR AQGK LFQM VTID QLKE M |
| 遺伝子ID: | 3792 |
| Uniprot: | P23276 |
| セルラーロケーション: | Cell membrane, Single-pass type II membrane protein |
| 計算された分子量: | 82kDa |
| 観察された分子量: | 120kDa |
| 同義語: | KEL, CD238, ECE3 |
| バックグラウンド: | This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. |
| UniProt Protein Function: | KEL: Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. Belongs to the peptidase M13 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.24.-; Protease Chromosomal Location of Human Ortholog: 7q33 Cellular Component: integral to membrane; plasma membrane Molecular Function:metalloendopeptidase activity; protein binding Biological Process: vasoconstriction Disease: Blood Group--kell System |
| NCBI Summary: | This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P23276 |
| NCBI GenInfo Identifier: | 1346376 |
| NCBI Gene ID: | 3792 |
| NCBI Accession: | P23276.2 |
| UniProt Secondary Accession: | P23276,Q96RS8, Q99885, B2RBV4, |
| UniProt Related Accession: | P23276 |
| Molecular Weight: | 82,824 Da |
| NCBI Full Name: | Kell blood group glycoprotein |
| NCBI Synonym Full Names: | Kell blood group, metallo-endopeptidase |
| NCBI Official Symbol: | KEL |
| NCBI Official Synonym Symbols: | ECE3; CD238 |
| NCBI Protein Information: | kell blood group glycoprotein |
| UniProt Protein Name: | Kell blood group glycoprotein |
| UniProt Synonym Protein Names: | CD_antigen: CD238 |
| Protein Family: | Kelch-like protein |
| UniProt Gene Name: | KEL |
| UniProt Entry Name: | KELL_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KEL antibody (CAB10116) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 20s. |
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