Anti-KDM8 Antibody (CAB11606)
- SKU:
- CAB11606
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KDM8 Antibody |
| 抗体コード: | CAB11606 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 147-416 of human KDM8 (NP_079049.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | LO2, Mouse eye, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 147-416 of human KDM8 (NP_079049.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | THLP GKRP ARGS LPEQ PCTK KARA DHGL IPDV KLEK TVPR LHRP SLQH FREQ FLVP GRPV ILKG VADH WPCM QKWS LEYI QEIA GCRT VPVE VGSR YTDE EWSQ TLMT VNEF ISKY IVNE PRDV GYLA QHQL FDQI PELK QDIS IPDY CSLG DGEE EEIT INAW FGPQ GTIS PLHQ DPQQ NFLV QVMG RKYI RLYS PQES GALY PHDT HLLH NTSQ VDVE NPDL EKFP KFAK APFL SCIL SPGE ILFI PVKY WHYV RALD LSFS VSFW WS |
| 遺伝子ID: | 79831 |
| Uniprot: | Q8N371 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 24kDa/47kDa/50kDa |
| 観察された分子量: | 55kDa |
| 同義語: | KDM8, JMJD5 |
| バックグラウンド: | This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | JMJD5: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Demethylase; EC 1.14.11.27 Chromosomal Location of Human Ortholog: 16p12.1 Cellular Component: cytosol; nucleoplasm; nucleus Molecular Function:chromatin binding; histone demethylase activity; histone demethylase activity (H3-K36 specific) Biological Process: G2/M transition of mitotic cell cycle; positive regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009] |
| UniProt Code: | Q8N371 |
| NCBI GenInfo Identifier: | 74728780 |
| NCBI Gene ID: | 79831 |
| NCBI Accession: | Q8N371.1 |
| UniProt Secondary Accession: | Q8N371,Q6VAK5, Q9H8B1, B4DLU9, |
| UniProt Related Accession: | Q8N371 |
| Molecular Weight: | 47kDa |
| NCBI Full Name: | Lysine-specific demethylase 8 |
| NCBI Synonym Full Names: | lysine demethylase 8 |
| NCBI Official Symbol: | KDM8 |
| NCBI Official Synonym Symbols: | JMJD5 |
| NCBI Protein Information: | lysine-specific demethylase 8 |
| UniProt Protein Name: | Lysine-specific demethylase 8 |
| UniProt Synonym Protein Names: | JmjC domain-containing protein 5; Jumonji domain-containing protein 5 |
| Protein Family: | Lysine-specific demethylase |
| UniProt Gene Name: | KDM8 |
 | Western blot analysis of extracts of various cell lines, using KDM8 antibody (CAB11606) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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