Anti-KDM5B Antibody (CAB7772)[KO Validated]
![Anti-KDM5B Antibody (CAB7772)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/18423/18289/anti-kdm5b-antibody-cab7772ko-validated__87922__96298.1645803959.jpg?c=1 "Anti-KDM5B Antibody (CAB7772)[KO Validated]")
- SKU:
- CAB7772
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
![Anti-KDM5B Antibody (CAB7772)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/18423/18289/anti-kdm5b-antibody-cab7772ko-validated__87922__96298.1645803959.jpg?c=1&imbypass=on "Anti-KDM5B Antibody (CAB7772)[KO Validated]")
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Description
| 抗体名: | Anti-KDM5B Antibody [KO Validated] |
| 抗体コード: | CAB7772 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 784-883 of human KDM5B (NP_006609.3). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 784-883 of human KDM5B (NP_006609.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EESE MKKF PDND LLRH LRLV TQDA EKCA SVAQ QLLN GKRQ TRYR SGGG KSQN QLTV NELR QFVT QLYA LPCV LSQT PLLK DLLN RVED FQQH SQKL LSEE |
| 遺伝子ID: | 10765 |
| Uniprot: | Q9UGL1 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 175kDa/179kDa |
| 観察された分子量: | 176KDa |
| 同義語: | KDM5B, CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A, RBP2-H1 |
| バックグラウンド: | This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | JARID1B: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Demethylase; Cancer Testis Antigen (CTA); EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:histone demethylase activity; histone demethylase activity (H3-K4 specific); protein binding; transcription corepressor activity; transcription factor activity |
| NCBI Summary: | This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing resultsi n multiple transcript variants. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q9UGL1 |
| NCBI GenInfo Identifier: | 296439317 |
| NCBI Gene ID: | 10765 |
| NCBI Accession: | Q9UGL1.3 |
| UniProt Secondary Accession: | Q9UGL1,O95811, Q15752, Q9Y3Q5, |
| UniProt Related Accession: | Q9UGL1 |
| Molecular Weight: | 179,409 Da |
| NCBI Full Name: | Lysine-specific demethylase 5B |
| NCBI Synonym Full Names: | lysine demethylase 5B |
| NCBI Official Symbol: | KDM5B |
| NCBI Official Synonym Symbols: | CT31; PLU1; PUT1; PLU-1; JARID1B; PPP1R98; RBP2-H1; RBBP2H1A |
| NCBI Protein Information: | lysine-specific demethylase 5B |
| UniProt Protein Name: | Lysine-specific demethylase 5B |
| UniProt Synonym Protein Names: | Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1 |
| Protein Family: | Lysine-specific demethylase |
| UniProt Gene Name: | KDM5B |
| UniProt Entry Name: | KDM5B_HUMAN |
![Anti-KDM5B Antibody [KO Validated] (CAB7772)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/n/662/A7772_1__70448.jpg) | Western blot analysis of extracts of 293T cells, using KDM5B antibody (CAB7772) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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