Anti-KCNU1 Antibody (CAB14967)
- SKU:
- CAB14967
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-KCNU1 Antibody |
| 抗体コード: | CAB14967 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 920-1149 of human KCNU1 (NP_001027006.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: | Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 920-1149 of human KCNU1 (NP_001027006.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LELL QMLV TGGV SSQL EQHL DKDK VYGV ADSC TSLL SGRN RCKL GLLS LHET ILSD VNPR NTFG QLFC GSLD LFGI LCVG LYRI IDEE ELNP ENKR FVIT RPAN EFKL LPSD LVFC AIPF STAC YKRN EEFS LQKS YEIV NKAS QTTE THSD TNCP PTID SVTE TLYS PVYS YQPR TNSL SFPK QIAW NQSR TNSI ISSQ IPLG DNAK ENER KTSD EVYD EDPF AYSE PL |
| 遺伝子ID: | 157855 |
| Uniprot: | A8MYU2 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 129kDa |
| 観察された分子量: | 130kDa |
| 同義語: | KCNU1, KCNMC1, KCa5, KCa5.1, Kcnma3, Slo3 |
| バックグラウンド: | This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K+. May represent the primary spermatozoan K+ current. In contrast to KCNMA1/SLO1, it is not activated by Ca2+ or Mg2+. Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. |
| NCBI Summary: | This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | A8MYU2 |
| NCBI GenInfo Identifier: | 157074214 |
| NCBI Gene ID: | 157855 |
| NCBI Accession: | NP_001027006.2 |
| UniProt Related Accession: | A8MYU2 |
| Molecular Weight: | 130 kDa |
| NCBI Full Name: | potassium channel subfamily U member 1 |
| NCBI Synonym Full Names: | potassium calcium-activated channel subfamily U member 1 |
| NCBI Official Symbol: | KCNU1 |
| NCBI Official Synonym Symbols: | KCa5; Slo3; KCNMC1; KCa5.1; Kcnma3 |
| NCBI Protein Information: | potassium channel subfamily U member 1 |
| UniProt Protein Name: | Potassium channel subfamily U member 1 |
| UniProt Synonym Protein Names: | Calcium-activated potassium channel subunit alpha-3; Calcium-activated potassium channel, subfamily M subunit alpha-3; KCa5; Slowpoke homolog 3 |
| Protein Family: | Potassium channel subfamily |
| UniProt Gene Name: | KCNU1 |
 | Western blot analysis of extracts of rat testis, using KCNU1 antibody (CAB14967) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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