Anti-KCNMB2 Antibody (CAB10277)
- SKU:
- CAB10277
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-KCNMB2 Antibody |
| 抗体コード: | CAB10277 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 68-194 of human KCNMB2 (NP_005823.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse kidney, Mouse brain, Mouse lung, Rat brain, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 68-194 of human KCNMB2 (NP_005823.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TLLR SYMQ SVWT EESQ CTLL NASI TETF NCSF SCGP DCWK LSQY PCLQ VYVN LTSS GEKL LLYH TEET IKIN QKCS YIPK CGKN FEES MSLV NVVM ENFR KYQH FSCY SDPE GNQK SVIL TKLY SSN |
| 遺伝子ID: | 10242 |
| Uniprot: | Q9Y691 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 27kDa |
| 観察された分子量: | 30kDa |
| 同義語: | KCNMB2 |
| バックグラウンド: | MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. |
| UniProt Protein Function: | KCNMB2: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3q26.32 Cellular Component: integral to plasma membrane; plasma membrane; voltage-gated potassium channel complex Molecular Function:calcium-activated potassium channel activity; ion channel inhibitor activity; potassium channel regulator activity Biological Process: detection of calcium ion; generation of action potential; potassium ion transport; regulation of action potential; regulation of vasoconstriction; synaptic transmission |
| NCBI Summary: | MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9Y691 |
| NCBI GenInfo Identifier: | 46396054 |
| NCBI Gene ID: | 10242 |
| NCBI Accession: | Q9Y691.1 |
| UniProt Related Accession: | Q9Y691 |
| Molecular Weight: | 27kDa |
| NCBI Full Name: | Calcium-activated potassium channel subunit beta-2 |
| NCBI Synonym Full Names: | potassium calcium-activated channel subfamily M regulatory beta subunit 2 |
| NCBI Official Symbol: | KCNMB2 |
| NCBI Protein Information: | calcium-activated potassium channel subunit beta-2 |
| UniProt Protein Name: | Calcium-activated potassium channel subunit beta-2 |
| UniProt Synonym Protein Names: | BK channel subunit beta-2; BKbeta2; Hbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; Hbeta3; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2 |
| Protein Family: | Calcium-activated potassium channel |
| UniProt Gene Name: | KCNMB2 |
 | Western blot analysis of extracts of various cell lines, using KCNMB2 antibody (CAB10277) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human appendix using KCNMB2 antibody (CAB10277) at dilution of 1:100 (40x lens). |
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