Anti-KCNMB1 Antibody (CAB10224)
- SKU:
- CAB10224
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-KCNMB1 Antibody |
| 抗体コード: | CAB10224 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-102 of human KCNMB1 (NP_004128.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | U-87MG, THP-1, MCF7 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-102 of human KCNMB1 (NP_004128.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TYYI LVTT VLPL YQKS VWTQ ESKC HLIE TNIR DQEE LKGK KVPQ YPCL WVNV SAAG RWAV LYHT EDTR DQNQ Q |
| 遺伝子ID: | 3779 |
| Uniprot: | Q16558 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 14kDa/21kDa |
| 観察された分子量: | 18kDa |
| 同義語: | KCNMB1, BKbeta1, K(VCA)beta, SLO-BETA, hbeta1, hslo-beta, k(VCA)beta-1, slo-beta-1 |
| バックグラウンド: | MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. |
| UniProt Protein Function: | KCNMB1: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 5q34 Cellular Component: plasma membrane; voltage-gated potassium channel complex Biological Process: detection of calcium ion; potassium ion transport; synaptic transmission Disease: Hypertension, Diastolic, Resistance To |
| NCBI Summary: | MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16558 |
| NCBI GenInfo Identifier: | 292495100 |
| NCBI Gene ID: | 3779 |
| NCBI Accession: | Q16558.5 |
| UniProt Secondary Accession: | Q16558,O00707, O00708, P78475, Q53YR0, Q8TAX3, Q93005 |
| UniProt Related Accession: | Q16558,AAB39373 |
| Molecular Weight: | 14,858 Da |
| NCBI Full Name: | Calcium-activated potassium channel subunit beta-1 |
| NCBI Synonym Full Names: | potassium calcium-activated channel subfamily M regulatory beta subunit 1 |
| NCBI Official Symbol: | KCNMB1 |
| NCBI Official Synonym Symbols: | hbeta1; BKbeta1; SLO-BETA; hslo-beta; K(VCA)beta; slo-beta-1; k(VCA)beta-1 |
| NCBI Protein Information: | calcium-activated potassium channel subunit beta-1 |
| UniProt Protein Name: | Calcium-activated potassium channel subunit beta-1 |
| UniProt Synonym Protein Names: | BK channel subunit beta-1; BKbeta; BKbeta1; Hbeta1; Calcium-activated potassium channel, subfamily M subunit beta-1; Calcium-activated potassium channel subunit beta; Charybdotoxin receptor subunit beta-1; K(VCA)beta-1; Maxi K channel subunit beta-1; Slo-beta-1; Slo-beta |
| Protein Family: | Calcium-activated potassium channel |
| UniProt Gene Name: | KCNMB1 |
| UniProt Entry Name: | KCMB1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KCNMB1 antibody (CAB10224) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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