Anti-KCNJ4 Antibody (CAB14010)
- SKU:
- CAB14010
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-KCNJ4 Antibody |
| 抗体コード: | CAB14010 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ4 (NP_004972.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SKOV3, Mouse skeletal muscle, Rat kidney |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ4 (NP_004972.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CVDT RWRY MLMI FSAA FLVS WLFF GLLF WCIA FFHG DLEA SPGV PAAG GPAA GGGG AAPV APKP CIMH VNGF LGAF LFSV ETQT TIGY GFRC VTEE CPLA V |
| 遺伝子ID: | 3761 |
| Uniprot: | P48050 |
| セルラーロケーション: | Cell junction, Cell membrane, Cytoplasmic vesicle membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| 計算された分子量: | 49kDa |
| 観察された分子量: | 49kDa |
| 同義語: | KCNJ4, HIR, HIRK2, HRK1, IRK-3, IRK3, Kir2.3 |
| バックグラウンド: | Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | HIR: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: basolateral plasma membrane; plasma membrane; voltage-gated potassium channel complex Molecular Function:G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; PDZ domain binding; protein binding Biological Process: potassium ion import; potassium ion transport |
| NCBI Summary: | Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48050 |
| NCBI GenInfo Identifier: | 1352483 |
| NCBI Gene ID: | 3761 |
| NCBI Accession: | P48050.1 |
| UniProt Secondary Accession: | P48050,Q14D44, |
| UniProt Related Accession: | P48050 |
| Molecular Weight: | 49,500 Da |
| NCBI Full Name: | Inward rectifier potassium channel 4 |
| NCBI Synonym Full Names: | potassium voltage-gated channel subfamily J member 4 |
| NCBI Official Symbol: | KCNJ4 |
| NCBI Official Synonym Symbols: | HIR; HRK1; IRK3; HIRK2; IRK-3; Kir2.3 |
| NCBI Protein Information: | inward rectifier potassium channel 4 |
| UniProt Protein Name: | Inward rectifier potassium channel 4 |
| UniProt Synonym Protein Names: | HIRK2; HRK1; Hippocampal inward rectifier; HIR; Inward rectifier K(+) channel Kir2.3; IRK-3; Potassium channel, inwardly rectifying subfamily J member 4 |
| Protein Family: | Inward rectifier potassium channel |
| UniProt Gene Name: | KCNJ4 |
| UniProt Entry Name: | KCNJ4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KCNJ4 antibody (CAB14010) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat brain using KCNJ4 antibody (CAB14010) at dilution of 1:100 (40x lens). |
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