| バックグラウンド: | This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. |
| UniProt Protein Function: | Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. |
| NCBI Summary: | This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q674X7 |
| NCBI GenInfo Identifier: | 172044653 |
| NCBI Gene ID: | 23254 |
| NCBI Accession: | Q674X7.2 |
| UniProt Secondary Accession: | Q674X7,Q5TGF1, Q674X4, Q674X6, Q6ZUD1, Q8IYN7, Q8N409 Q9UIL2, Q9UPX4, B0QYQ0, B1AK78, |
| UniProt Related Accession: | Q674X7 |
| Molecular Weight: | 46,250 Da |
| NCBI Full Name: | Kazrin |
| NCBI Synonym Full Names: | kazrin, periplakin interacting protein |
| NCBI Official Symbol: | KAZN |
| NCBI Official Synonym Symbols: | KAZ |
| NCBI Protein Information: | kazrin |
| UniProt Protein Name: | Kazrin |
| Protein Family: | Kazrin |
| UniProt Gene Name: | KAZN |
| UniProt Entry Name: | KAZRN_HUMAN |
