Anti-Kaiso/ZBTB33 Antibody (CAB3770)
- SKU:
- CAB3770
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ZNF-kaiso
- Synonyms:
- ZNF348
Frequently bought together:
Description
| 抗体名: | Kaiso/ZBTB33 Rabbit mAb |
| 抗体コード: | CAB3770 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | ZNF-kaiso, ZNF348 |
| 申し込み: | WB, IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human Kaiso/ZBTB33 |
| 申し込み: | WB, IF |
| 推奨される希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, SH-SY5Y, Rat brain |
| 免疫原: | A synthesized peptide derived from human Kaiso/ZBTB33 |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 10009 |
| Uniprot: | Q86T24 |
| 計算された分子量: | 85kDa |
| 観察された分子量: | 74KDa |
| UniProt Protein Function: | Kaiso: Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: Xq24 Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; plasma membrane Molecular Function:methyl-CpG binding; protein binding; sequence-specific DNA binding Biological Process: negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010] |
| UniProt Code: | Q86T24 |
| NCBI GenInfo Identifier: | 84029319 |
| NCBI Gene ID: | 10009 |
| NCBI Accession: | Q86T24.2 |
| UniProt Secondary Accession: | Q86T24,O00319, Q7Z361, Q8IVP6, Q8N3P0, B2R5U6, |
| UniProt Related Accession: | Q86T24 |
| Molecular Weight: | 74kDa |
| NCBI Full Name: | Transcriptional regulator Kaiso |
| NCBI Synonym Full Names: | zinc finger and BTB domain containing 33 |
| NCBI Official Symbol: | ZBTB33 |
| NCBI Official Synonym Symbols: | ZNF348; ZNF-kaiso |
| NCBI Protein Information: | transcriptional regulator Kaiso |
| UniProt Protein Name: | Transcriptional regulator Kaiso |
| UniProt Synonym Protein Names: | Zinc finger and BTB domain-containing protein 33 |
| Protein Family: | Transcriptional regulator |
| UniProt Gene Name: | ZBTB33 |