Anti-JNK3 Antibody (CAB2112)
- SKU:
- CAB2112
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-JNK3 Antibody |
抗体コード: | CAB2112 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 175-464 of human JNK3 (NP_620448.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse |
ポジティブサンプル: | Mouse brain, Mouse testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 175-464 of human JNK3 (NP_620448.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | CGIK HLHS AGII HRDL KPSN IVVK SDCT LKIL DFGL ARTA GTSF MMTP YVVT RYYR APEV ILGM GYKE NVDI WSVG CIMG EMVR HKIL FPGR DYID QWNK VIEQ LGTP CPEF MKKL QPTV RNYV ENRP KYAG LTFP KLFP DSLF PADS EHNK LKAS QARD LLSK MLVI DPAK RISV DDAL QHPY INVW YDPA EVEA PPPQ IYDK QLDE REHT IEEW KELI YKEV MNSE EKTK NGVV KGQP SPSG AAVN SSES LPPS SSVN DISS MSTD QTLA SDTD SSLE ASAG PLGC CR |
遺伝子ID: | 5602 |
Uniprot: | P53779 |
セルラーロケーション: | Cytoplasm, Lipid-anchor, Membrane, Mitochondrion, Nucleus |
計算された分子量: | 48kDa/52kDa |
観察された分子量: | 48kDa |
同義語: | JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, MAPK10 |
バックグラウンド: | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. |
UniProt Protein Function: | Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). |
NCBI Summary: | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015] |
UniProt Code: | P53779 |
NCBI GenInfo Identifier: | 2507196 |
NCBI Gene ID: | 5602 |
NCBI Accession: | P53779.2 |
UniProt Secondary Accession: | P53779,Q15707, Q49AP1, A6NFS3, A6NG28, B3KQ94, |
UniProt Related Accession: | P53779 |
Molecular Weight: | 31,933 Da |
NCBI Full Name: | Mitogen-activated protein kinase 10 |
NCBI Synonym Full Names: | mitogen-activated protein kinase 10 |
NCBI Official Symbol: | MAPK10 |
NCBI Official Synonym Symbols: | JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK |
NCBI Protein Information: | mitogen-activated protein kinase 10 |
UniProt Protein Name: | Mitogen-activated protein kinase 10 |
UniProt Synonym Protein Names: | MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3 |
UniProt Gene Name: | MAPK10 |
UniProt Entry Name: | MK10_HUMAN |
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