| UniProt Protein Function: | Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). |
| NCBI Summary: | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015] |
| UniProt Code: | P53779 |
| NCBI GenInfo Identifier: | 2507196 |
| NCBI Gene ID: | 5602 |
| NCBI Accession: | P53779.2 |
| UniProt Secondary Accession: | P53779,Q15707, Q49AP1, A6NFS3, A6NG28, B3KQ94, |
| UniProt Related Accession: | P53779 |
| Molecular Weight: | 31,933 Da |
| NCBI Full Name: | Mitogen-activated protein kinase 10 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase 10 |
| NCBI Official Symbol: | MAPK10 |
| NCBI Official Synonym Symbols: | JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK |
| NCBI Protein Information: | mitogen-activated protein kinase 10 |
| UniProt Protein Name: | Mitogen-activated protein kinase 10 |
| UniProt Synonym Protein Names: | MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3 |
| UniProt Gene Name: | MAPK10 |
| UniProt Entry Name: | MK10_HUMAN |
