Anti-JAG2 Antibody (CAB14247)
- SKU:
- CAB14247
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-JAG2 Antibody |
| 抗体コード: | CAB14247 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-200 of human JAG2 (NP_002217.3). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse thymus, Rat thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-200 of human JAG2 (NP_002217.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ARPM GYFE LQLS ALRN VNGE LLSG ACCD GDGR TTRA GGCG HDEC DTYV RVCL KEYQ AKVT PTGP CSYG HGAT PVLG GNSF YLPP AGAA GDRA RARA RAGG DQDP GLVV IPFQ FAWP RSFT LIVE AWDW DNDT TPNE ELLI ERVS HAGM INPE DRWK SLHF SGHV AHLE LQIR VRCD E |
| 遺伝子ID: | 3714 |
| Uniprot: | Q9Y219 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 129kDa/133kDa |
| 観察された分子量: | 175kDa |
| 同義語: | JAG2, HJ2, SER2, jagged 2 |
| バックグラウンド: | The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | JAG2: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development. Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell surface Chromosomal Location of Human Ortholog: 14q32 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding; growth factor activity; calcium ion binding; Notch binding Biological Process: regulation of cell adhesion; thymic T cell selection; Notch signaling pathway; in utero embryonic development; Notch receptor processing; cell cycle; regulation of cell migration; odontogenesis of dentine-containing teeth; regulation of cell proliferation; respiratory system process; morphogenesis of embryonic epithelium; spermatogenesis; cell differentiation; auditory receptor cell fate commitment; skeletal development; gamma-delta T cell differentiation; T cell differentiation |
| NCBI Summary: | The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y219 |
| NCBI GenInfo Identifier: | 21704277 |
| NCBI Gene ID: | 3714 |
| NCBI Accession: | NP_002217.3 |
| UniProt Secondary Accession: | Q9Y219,Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0, |
| UniProt Related Accession: | Q9Y219 |
| Molecular Weight: | |
| NCBI Full Name: | protein jagged-2 isoform a |
| NCBI Synonym Full Names: | jagged 2 |
| NCBI Official Symbol: | JAG2 |
| NCBI Official Synonym Symbols: | HJ2; SER2 |
| NCBI Protein Information: | protein jagged-2 |
| UniProt Protein Name: | Protein jagged-2 |
| Protein Family: | Protein jagged |
| UniProt Gene Name: | JAG2 |
| UniProt Entry Name: | JAG2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using JAG2 antibody (CAB14247) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of C6 cells using JAG2 antibody (CAB14247) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using JAG2 antibody (CAB14247) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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