Anti-JAG1 Antibody (CAB12733)
- SKU:
- CAB12733
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-JAG1 Antibody |
| 抗体コード: | CAB12733 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-180 of human JAG1 (NP_000205.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-180 of human JAG1 (NP_000205.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QFEL EILS MQNV NGEL QNGN CCGG ARNP GDRK CTRD ECDT YFKV CLKE YQSR VTAG GPCS FGSG STPV IGGN TFNL KASR GNDR NRIV LPFS FAWP RSYT LLVE AWDS SNDT VQPD SIIE KASH SGMI NPSR QWQT LKQN TGVA HFE |
| 遺伝子ID: | 182 |
| Uniprot: | P78504 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 116kDa/133kDa |
| 観察された分子量: | 160kDa |
| 同義語: | JAG1, AGS, AGS1, AHD, AWS, CD339, HJ1, JAGL1, jagged 1 |
| バックグラウンド: | The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. |
| UniProt Protein Function: | JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 20p12.2 Cellular Component: adherens junction; apical plasma membrane; membrane; plasma membrane Molecular Function:Notch binding; phospholipid binding; protein binding Biological Process: Notch receptor processing; Notch signaling pathway; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; T cell mediated immunity Disease: Alagille Syndrome 1; Tetralogy Of Fallot |
| NCBI Summary: | The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78504 |
| NCBI GenInfo Identifier: | 20455033 |
| NCBI Gene ID: | 182 |
| NCBI Accession: | P78504.3 |
| UniProt Secondary Accession: | P78504,O14902, O15122, Q15816, A0AV43, B4DYR1, E9PCF9 |
| UniProt Related Accession: | P78504 |
| Molecular Weight: | 134kDa |
| NCBI Full Name: | Protein jagged-1 |
| NCBI Synonym Full Names: | jagged 1 |
| NCBI Official Symbol: | JAG1 |
| NCBI Official Synonym Symbols: | AGS; AHD; AWS; HJ1; AGS1; CD339; JAGL1 |
| NCBI Protein Information: | protein jagged-1 |
| UniProt Protein Name: | Protein jagged-1 |
| UniProt Synonym Protein Names: | CD_antigen: CD339 |
| Protein Family: | Protein jagged |
| UniProt Gene Name: | JAG1 |
 | Western blot analysis of extracts of HeLa cells, using JAG1 antibody (CAB12733) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of NIH/3T3 cells using JAG1 antibody (CAB12733) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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