Anti-ITIH1 Antibody (CAB10833)
- SKU:
- CAB10833
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ITIH1 Antibody |
| 抗体コード: | CAB10833 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 530-670 of human ITIH1 (NP_002206.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | LO2, heLa, U-251MG, 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 530-670 of human ITIH1 (NP_002206.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | HGEG QEFS ITCL VDEE EMKK LLRE RGHM LENH VERL WAYL TIQE LLAK RMKV DREE RANL SSQA LQMS LDYG FVTP LTSM SIRG MADQ DGLK PTID KPSE DSPP LEML GPRR TFVL SALQ PSPT HSSS NTQR LPDR VTGV D |
| 遺伝子ID: | 3697 |
| Uniprot: | P19827 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 69kDa/86kDa/101kDa |
| 観察された分子量: | 115kDa |
| 同義語: | ITIH1, H1P, IATIH, IGHEP1, ITI-HC1, ITIH, SHAP |
| バックグラウンド: | This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. |
| UniProt Protein Function: | ITIH1: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Belongs to the ITIH family. |
| UniProt Protein Details: | Protein type:Inhibitor; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3p21.1 Molecular Function:calcium ion binding |
| NCBI Summary: | This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P19827 |
| NCBI GenInfo Identifier: | 2851501 |
| NCBI Gene ID: | 3697 |
| NCBI Accession: | P19827.3 |
| UniProt Secondary Accession: | P19827,P78455, Q01746, Q562G1, A8K9N5, B2RAH9, B7Z558 B7Z8C0, F5H165, F5H7Y8, |
| UniProt Related Accession: | P19827 |
| Molecular Weight: | 101kDa |
| NCBI Full Name: | Inter-alpha-trypsin inhibitor heavy chain H1 |
| NCBI Synonym Full Names: | inter-alpha-trypsin inhibitor heavy chain 1 |
| NCBI Official Symbol: | ITIH1 |
| NCBI Official Synonym Symbols: | H1P; ITIH; SHAP; IATIH; IGHEP1; ITI-HC1 |
| NCBI Protein Information: | inter-alpha-trypsin inhibitor heavy chain H1 |
| UniProt Protein Name: | Inter-alpha-trypsin inhibitor heavy chain H1 |
| UniProt Synonym Protein Names: | Inter-alpha-trypsin inhibitor complex component III; Serum-derived hyaluronan-associated protein; SHAP |
| Protein Family: | Inter-alpha-trypsin inhibitor |
| UniProt Gene Name: | ITIH1 |
 | Western blot analysis of extracts of various cell lines, using ITIH1 antibody (CAB10833) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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