Anti-ITGA1 Antibody (CAB16054)
- SKU:
- CAB16054
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
抗体名: | Anti-ITGA1 Antibody |
抗体コード: | CAB16054 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human ITGA1 (NP_852478.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse kidney, Rat lung |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human ITGA1 (NP_852478.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ATVC FDVK LKSK EDTI YEAD LQYR VTLD SLRQ ISRS FFSG TQER KVQR NITV RKSE CTKH SFYM LDKH DFQD SVRI TLDF NLTD PENG PVLD DSLP NSVH E |
遺伝子ID: | 3672 |
Uniprot: | P56199 |
セルラーロケーション: | Membrane, Single-pass type I membrane protein |
計算された分子量: | 130kDa |
観察された分子量: | 200kDa |
同義語: | ITGA1, CD49a, VLA1 |
バックグラウンド: | This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. |
UniProt Protein Function: | ITGA1: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Belongs to the integrin alpha chain family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5q11.2 Cellular Component: neuron projection; focal adhesion; cell surface; membrane; plasma membrane; acrosome; perikaryon; integrin complex; lipid raft; external side of plasma membrane Molecular Function:collagen binding; protein binding; metal ion binding; protein phosphatase binding; receptor binding Biological Process: positive regulation of phosphoprotein phosphatase activity; integrin-mediated signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; axon guidance; neutrophil chemotaxis; extracellular matrix organization and biogenesis; activation of MAPK activity; cell-matrix adhesion; vasodilation; negative regulation of cell proliferation; muscle contraction; cellular extravasation; positive regulation of neuron apoptosis; blood coagulation |
NCBI Summary: | This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008] |
UniProt Code: | P56199 |
NCBI GenInfo Identifier: | 124056463 |
NCBI Gene ID: | 3672 |
NCBI Accession: | P56199.2 |
UniProt Secondary Accession: | P56199,B2RNU0, |
UniProt Related Accession: | P56199 |
Molecular Weight: | 130,848 Da |
NCBI Full Name: | Integrin alpha-1 |
NCBI Synonym Full Names: | integrin, alpha 1 |
NCBI Official Symbol: | ITGA1 |
NCBI Official Synonym Symbols: | VLA1; CD49a |
NCBI Protein Information: | integrin alpha-1; VLA-1; laminin and collagen receptor; very late activation protein 1; CD49 antigen-like family member A |
UniProt Protein Name: | Integrin alpha-1 |
UniProt Synonym Protein Names: | CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD_antigen: CD49a |
Protein Family: | Integrin |
UniProt Gene Name: | ITGA1 |
UniProt Entry Name: | ITA1_HUMAN |