Anti-IRF8 Antibody (CAB5798)
- SKU:
- CAB5798
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
| 抗体名: | Anti-IRF8 Antibody |
| 抗体コード: | CAB5798 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 137-426 of human IRF8 (NP_002154.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HL-60, THP-1, Mouse spleen |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 137-426 of human IRF8 (NP_002154.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ECGR SEID ELIK EPSV DDYM GMIK RSPS PPEA CRSQ LLPD WWAQ QPST GVPL VTGY TTYD AHHS AFSQ MVIS FYYG GKLV GQAT TTCP EGCR LSLS QPGL PGTK LYGP EGLE LVRF PPAD AIPS ERQR QVTR KLFG HLER GVLL HSSR QGVF VKRL CQGR VFCS GNAV VCKG RPNK LERD EVVQ VFDT SQFF RELQ QFYN SQGR LPDG RVVL CFGE EFPD MAPL RSKL ILVQ IEQL YVRQ LAEE AGKS CGAG SVMQ APEE PPPD QVFR MFPD ICAS HQRS FFRE NQQI TV |
| 遺伝子ID: | 3394 |
| Uniprot: | Q02556 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 48kDa |
| 観察された分子量: | 53kDa |
| 同義語: | IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8 |
| バックグラウンド: | Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. |
| UniProt Protein Function: | IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 16q24.1 Cellular Component: nucleoplasm; cytosol Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; protein binding Biological Process: transcription from RNA polymerase II promoter; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; defense response to bacterium; myeloid cell differentiation; immune response; negative regulation of transcription from RNA polymerase II promoter; defense response to protozoan; phagocytosis Disease: Monocyte And Dendritic Cell Deficiency, Autosomal Recessive; Immunodeficiency 32a |
| NCBI Summary: | Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q02556 |
| NCBI GenInfo Identifier: | 6016308 |
| NCBI Gene ID: | 3394 |
| NCBI Accession: | Q02556.2 |
| UniProt Secondary Accession: | Q02556,A0AV82, |
| UniProt Related Accession: | Q02556 |
| Molecular Weight: | Calculated MW: 48kDaObserved MW: 53kDa |
| NCBI Full Name: | Interferon regulatory factor 8 |
| NCBI Synonym Full Names: | interferon regulatory factor 8 |
| NCBI Official Symbol: | IRF8 |
| NCBI Official Synonym Symbols: | ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP |
| NCBI Protein Information: | interferon regulatory factor 8; interferon consensus sequence binding protein 1 |
| UniProt Protein Name: | Interferon regulatory factor 8 |
| UniProt Synonym Protein Names: | Interferon consensus sequence-binding protein; H-ICSBP; ICSBP |
| Protein Family: | Interferon regulatory factor |
| UniProt Gene Name: | IRF8 |
| UniProt Entry Name: | IRF8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IRF8 antibody (CAB5798) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 15s. |
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