| UniProt Protein Function: | IPO9: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of H2B histone, RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4 and RPL6. Belongs to the importin beta family. |
| UniProt Protein Details: | Protein type:Karyopherin; Nuclear import Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: cytoplasm; membrane Molecular Function:histone binding; protein binding; protein transporter activity |
| UniProt Code: | Q96P70 |
| NCBI GenInfo Identifier: | 41688593 |
| NCBI Gene ID: | 55705 |
| NCBI Accession: | Q96P70.3 |
| UniProt Secondary Accession: | Q96P70,Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8 Q9ULM8, B1ASV5, |
| UniProt Related Accession: | Q96P70 |
| Molecular Weight: | 116kDa |
| NCBI Full Name: | Importin-9 |
| NCBI Synonym Full Names: | importin 9 |
| NCBI Official Symbol: | IPO9 |
| NCBI Official Synonym Symbols: | Imp9 |
| NCBI Protein Information: | importin-9 |
| UniProt Protein Name: | Importin-9 |
| UniProt Synonym Protein Names: | Ran-binding protein 9; RanBP9 |
| Protein Family: | Importin |
| UniProt Gene Name: | IPO9 |
