Anti-IPO7 Antibody (CAB18417)
- SKU:
- CAB18417
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-IPO7 Antibody |
| 抗体コード: | CAB18417 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human IPO7. |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-251MG, HepG2, HeLa, Mouse heart, Mouse brain, Rat brain |
| 免疫原: | A synthetic peptide of human IPO7. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 10527 |
| Uniprot: | O95373 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 130kDa |
 | Western blot - IPO7 Rabbit pAb (CAB18417) |
| 同義語: | Imp7, RANBP7, IPO7 |
| バックグラウンド: |
| UniProt Protein Function: | IPO7: a beta importin protein. Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin beta-1 subunit. A receptor for nuclear localization signals (NLS) that promotes translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. |
| UniProt Protein Details: | Protein type:Nuclear import; Karyopherin; Nuclear export Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: nucleoplasm; membrane; cytoplasm; nuclear pore Molecular Function:protein binding; histone binding; transporter activity; Ran GTPase binding Biological Process: viral reproduction; protein import into nucleus; regulation of catalytic activity; innate immune response; signal transduction |
| NCBI Summary: | The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95373 |
| NCBI GenInfo Identifier: | 5453998 |
| NCBI Gene ID: | 10527 |
| NCBI Accession: | NP_006382.1 |
| UniProt Secondary Accession: | O95373,Q1RMF7, Q9H177, Q9NTE3, A6NNM5, B2R786, |
| UniProt Related Accession: | O95373 |
| Molecular Weight: | 119517 |
| NCBI Full Name: | importin-7 |
| NCBI Synonym Full Names: | importin 7 |
| NCBI Official Symbol: | IPO7 |
| NCBI Official Synonym Symbols: | Imp7; RANBP7 |
| NCBI Protein Information: | importin-7 |
| UniProt Protein Name: | Importin-7 |
| UniProt Synonym Protein Names: | Ran-binding protein 7; RanBP7 |
| Protein Family: | Importin |
| UniProt Gene Name: | IPO7 |
| UniProt Entry Name: | IPO7_HUMAN |