Anti-IPO4 Antibody (CAB19902)[KO Validated]
- SKU:
- CAB19902
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-IPO4 Antibody [KO Validated] |
抗体コード: | CAB19902 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human IPO4. |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T |
免疫原: | Recombinant protein of human IPO4. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 79711 |
Uniprot: | Q8TEX9 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 119kDa |
観察された分子量: | 130KDa |
同義語: | IPO4, Imp4 |
バックグラウンド: |
UniProt Protein Function: | IPO4: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear import; Karyopherin Chromosomal Location of Human Ortholog: 14q12 Cellular Component: protein complex; membrane; nuclear chromatin; cytoplasm; nuclear pore Molecular Function:protein binding; Ran GTPase binding Biological Process: intracellular protein transport; protein transport; DNA replication-independent nucleosome assembly; DNA replication-dependent nucleosome assembly |
UniProt Code: | Q8TEX9 |
NCBI GenInfo Identifier: | 62460637 |
NCBI Gene ID: | 79711 |
NCBI Accession: | NP_078934.3 |
UniProt Secondary Accession: | Q8TEX9,Q2NL96, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0 B2RN95, |
UniProt Related Accession: | Q8TEX9 |
Molecular Weight: | 118,715 Da |
NCBI Full Name: | importin-4 |
NCBI Synonym Full Names: | importin 4 |
NCBI Official Symbol: | IPO4 |
NCBI Official Synonym Symbols: | Imp4 |
NCBI Protein Information: | importin-4; imp4b; ranBP4; importin-4b; ran-binding protein 4 |
UniProt Protein Name: | Importin-4 |
UniProt Synonym Protein Names: | Importin-4b; Imp4b; Ran-binding protein 4; RanBP4 |
Protein Family: | Importin |
UniProt Gene Name: | IPO4 |
UniProt Entry Name: | IPO4_HUMAN |