| UniProt Protein Function: | INTS8: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 8q22.1 Cellular Component: integrator complex; nucleoplasm Molecular Function:protein binding Biological Process: snRNA processing; snRNA transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] |
| UniProt Code: | Q75QN2 |
| NCBI GenInfo Identifier: | 70608109 |
| NCBI Gene ID: | 55656 |
| NCBI Accession: | NP_060334.2 |
| UniProt Secondary Accession: | Q75QN2,Q5RKZ3, Q6P1R5, Q7Z314, Q9NVS6, Q9NWY7, B2RN92 |
| UniProt Related Accession: | Q75QN2 |
| Molecular Weight: | 111,116 Da |
| NCBI Full Name: | integrator complex subunit 8 |
| NCBI Synonym Full Names: | integrator complex subunit 8 |
| NCBI Official Symbol: | INTS8 |
| NCBI Official Synonym Symbols: | INT8; C8orf52 |
| NCBI Protein Information: | integrator complex subunit 8 |
| UniProt Protein Name: | Integrator complex subunit 8 |
| UniProt Synonym Protein Names: | Protein kaonashi-1 |
| UniProt Gene Name: | INTS8 |
