Anti-INTS7 Antibody (CAB16113)

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SKU:
CAB16113
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
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Description

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抗体名:Anti-INTS7 Antibody
抗体コード:CAB16113
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 702-948 of human INTS7 (NP_001186740.1).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse
ポジティブサンプル:Raji, A-431, U-87MG, HeLa, Mouse testis
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 702-948 of human INTS7 (NP_001186740.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:NVEL QQQS CLLI SHAI EALI LDPE SASF QEYG STGT AHAD SEYE RRMM SVYN HVLE EHTA CLCN AIIA LLKV PLSF QRYF FQKL QSTS IKLA LSPS PRNP AEPI AVQN NQQL ALKV EGVV QHGS KPGL FRKI QSVC LNVS STLQ SKSG QDYK IPID NMTN EMEQ RVEP HNDY FSTQ FLLN FAIL GTHN ITVE SSVK DANG IVWK TGPR TTIF VKSL EDPY SQQI RLQQ QQAQ QPLQ QQQQ RNAY TRF
遺伝子ID:25896
Uniprot:Q9NVH2
セルラーロケーション:Chromosome, Nucleus
計算された分子量:101kDa/104kDa/105kDa/106kDa
観察された分子量:107kDa
同義語:INTS7, C1orf73, INT7
バックグラウンド:This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:INTS7: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. Belongs to the Integrator subunit 7 family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 1q32.3

Cellular Component: chromosome; integrator complex; nucleoplasm

Molecular Function:protein binding

Biological Process: DNA damage checkpoint; snRNA processing; snRNA transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q9NVH2
NCBI GenInfo Identifier:34189576
NCBI Gene ID:25896
NCBI Accession:BC020523
UniProt Secondary Accession:Q9NVH2,Q8N4K7, Q8WUH5, Q9H9V3, Q9NVU5, Q9UFC6, Q9UFM3 B4DLZ6, B7WNP6, B7WPB6,
UniProt Related Accession:Q9NVH2
Molecular Weight:101,118 Da
NCBI Full Name:Homo sapiens integrator complex subunit 7, mRNA
NCBI Synonym Full Names:integrator complex subunit 7
NCBI Official Symbol:INTS7  
NCBI Official Synonym Symbols:INT7; C1orf73  
NCBI Protein Information:integrator complex subunit 7
UniProt Protein Name:Integrator complex subunit 7
Protein Family:Integrator complex
UniProt Gene Name:INTS7  
UniProt Entry Name:INT7_HUMAN
Anti-INTS7 Antibody (CAB16113)Western blot analysis of extracts of various cell lines, using INTS7 antibody (CAB16113) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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