Anti-INPPL1 Antibody (CAB10115)
- SKU:
- CAB10115
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-INPPL1 Antibody |
| 抗体コード: | CAB10115 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-310 of human INPPL1 (NP_001558.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, U-251MG, A-549, BT-474, Mouse heart, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-310 of human INPPL1 (NP_001558.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GLYA QPNQ GLVC ALLL PVEG EREP DPPD DRDA SDGE DEKP PLPP RSGS TSIS APTG PSSP LPAP ETPT APAA ESAP NGLS TVSH DYLK GSYG LDLE AVRG GASH LPHL TRTL ATSC RRLH SEVD KVLS GLEI LSKV FDQQ SSPM VTRL LQQQ NLPQ TGEQ ELES LVLK LSVL KDFL SGIQ KKAL KALQ DMSS TAPP APQP STRK AKTI PVQ |
| 遺伝子ID: | 3636 |
| Uniprot: | O15357 |
| セルラーロケーション: | Cell projection, Cytoplasm, Membrane, Peripheral membrane protein, cytoskeleton, cytosol, filopodium, lamellipodium |
| 計算された分子量: | 113kDa/138kDa |
| 観察された分子量: | 160kDa |
| 同義語: | INPPL1, OPSMD, SHIP2 |
| バックグラウンド: | The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. |
| UniProt Protein Function: | SHIP-2: an SH2-containing inositol phosphatase. Recruited to activated receptor complexes including insulin R, PDGFR and Fc-gamma-R. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; Phosphatase, lipid; Motility/polarity/chemotaxis; EC 3.1.3.86 Chromosomal Location of Human Ortholog: 11q13 Cellular Component: Golgi apparatus; cytoskeleton; lamellipodium; cytoplasm; plasma membrane; cytosol; filopodium Molecular Function:protein binding; hydrolase activity; SH2 domain binding; actin binding; SH3 domain binding Biological Process: inositol phosphate metabolic process; immune system process; actin filament organization; glucose metabolic process; endocytosis; response to insulin stimulus; post-embryonic development; negative regulation of cell proliferation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; cell adhesion; endochondral ossification Disease: Opsismodysplasia |
| NCBI Summary: | The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009] |
| UniProt Code: | O15357 |
| NCBI GenInfo Identifier: | 269849650 |
| NCBI Gene ID: | 3636 |
| NCBI Accession: | O15357.2 |
| UniProt Secondary Accession: | O15357,Q13577, Q13578, B2RTX5, |
| UniProt Related Accession: | O15357 |
| Molecular Weight: | 113,176 Da |
| NCBI Full Name: | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
| NCBI Synonym Full Names: | inositol polyphosphate phosphatase-like 1 |
| NCBI Official Symbol: | INPPL1 |
| NCBI Official Synonym Symbols: | OPSMD; SHIP2 |
| NCBI Protein Information: | phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; SHIP-2; INPPL-1; 51C protein; protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 |
| UniProt Protein Name: | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
| UniProt Synonym Protein Names: | Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SHIP-2 |
| UniProt Gene Name: | INPPL1 |
| UniProt Entry Name: | SHIP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using INPPL1 antibody (CAB10115) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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