Anti-INPP5E Antibody (CAB17735)
- SKU:
- CAB17735
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
抗体名: | Anti-INPP5E Antibody |
抗体コード: | CAB17735 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 510-630 of human INPP5E (NP_063945.2). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SH-SY5Y |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 510-630 of human INPP5E (NP_063945.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LIRE MRKG SIFK GFQE PDIH FLPS YKFD IGKD TYDS TSKQ RTPS YTDR VLYR SRHK GDIC PVSY SSCP GIKT SDHR PVYG LFRV KVRP GRDN IPLA AGKF DREL YLLG IKRR ISKE IQRQ Q |
遺伝子ID: | 56623 |
Uniprot: | Q9NRR6 |
セルラーロケーション: | |
計算された分子量: | 66kDa/70kDa |
観察された分子量: | 80kDa |
同義語: | CORS1, CPD4, JBTS1, MORMS, PPI5PIV, pharbin, INPP5E |
バックグラウンド: | The protein encoded by this gene is an inositol 1, 4, 5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1, 4, 5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3, 4, 5-trisphosphate and phosphatidylinositol 3, 5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
UniProt Protein Function: | Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates. |
NCBI Summary: | The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
UniProt Code: | Q9NRR6 |
NCBI GenInfo Identifier: | 972781524 |
NCBI Gene ID: | 56623 |
NCBI Accession: | NP_001305431.1 |
UniProt Secondary Accession: | Q9NRR6,Q15734, Q6PIV5, |
UniProt Related Accession: | Q9NRR6 |
Molecular Weight: | 70 |
NCBI Full Name: | 72 kDa inositol polyphosphate 5-phosphatase isoform 2 |
NCBI Synonym Full Names: | inositol polyphosphate-5-phosphatase E |
NCBI Official Symbol: | INPP5E |
NCBI Official Synonym Symbols: | CPD4; CORS1; JBTS1; MORMS; PPI5PIV; pharbin |
NCBI Protein Information: | 72 kDa inositol polyphosphate 5-phosphatase |
UniProt Protein Name: | 72 kDa inositol polyphosphate 5-phosphatase |
UniProt Synonym Protein Names: | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV |
UniProt Gene Name: | INPP5E |