Anti-INMT Antibody (CAB14391)
- SKU:
- CAB14391
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-INMT Antibody |
| 抗体コード: | CAB14391 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human INMT (NP_006765.4). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse liver, Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human INMT (NP_006765.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MKGG FTGG DEYQ KHFL PRDY LATY YSFD GSPS PEAE MLKF NLEC LHKT FGPG GLQG DTLI DIGS GPTI YQVL AACD SFQD ITLS DFTD RNRE ELEK WLKK EPGA YDWT PAVK FACE LEGN SGRW EEKE EKLR AAVK RVLK CDVH LGNP LAPA VLPL ADCV LTLL AMEC ACCS LDAY RAAL CNLA SLLK PGGH LVTT VTLR LPSY MVGK REFS CVAL EKEE VEQA VLDA GFDI EQLL HSPQ SYSV TNAA NNGV CFIV ARKK PGP |
| 遺伝子ID: | 11185 |
| Uniprot: | O95050 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 28kDa |
| 観察された分子量: | 29kDa |
| 同義語: | INMT, TEMT |
| バックグラウンド: | N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. |
| UniProt Protein Function: | INMT: Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2- methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. Catalyzes the N-methylation of tryptamine and structurally related compounds. Belongs to the NNMT/PNMT/TEMT family. |
| UniProt Protein Details: | Protein type:EC 2.1.1.96; Methyltransferase; EC 2.1.1.49; Amino Acid Metabolism - tryptophan Chromosomal Location of Human Ortholog: 7p14.3 Cellular Component: cytosol Molecular Function:amine N-methyltransferase activity; protein binding; thioether S-methyltransferase activity Biological Process: amine metabolic process; methylation; response to toxin; selenium metabolic process |
| NCBI Summary: | N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010] |
| UniProt Code: | O95050 |
| NCBI GenInfo Identifier: | 312836856 |
| NCBI Gene ID: | 11185 |
| NCBI Accession: | NP_001186148.1 |
| UniProt Secondary Accession: | O95050,Q3KP49, Q9P1Y2, Q9UBY4, Q9UHQ0, B8ZZ69, |
| UniProt Related Accession: | O95050 |
| Molecular Weight: | 44.9 kDa |
| NCBI Full Name: | indolethylamine N-methyltransferase isoform 2 |
| NCBI Synonym Full Names: | indolethylamine N-methyltransferase |
| NCBI Official Symbol: | INMT |
| NCBI Official Synonym Symbols: | TEMT |
| NCBI Protein Information: | indolethylamine N-methyltransferase |
| UniProt Protein Name: | Indolethylamine N-methyltransferase |
| UniProt Synonym Protein Names: | Aromatic alkylamine N-methyltransferase; Amine N-methyltransferase; Arylamine N-methyltransferase; Thioether S-methyltransferase; TEMT |
| Protein Family: | Indolethylamine N-methyltransferase |
| UniProt Gene Name: | INMT |
| UniProt Entry Name: | INMT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using INMT Rabbit pAb (CAB14391) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using INMT antibody (CAB14391) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using INMT antibody (CAB14391) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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