Anti-ING5 Antibody (CAB7288)[KO Validated]
![Anti-ING5 Antibody (CAB7288)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/26177/26025/anti-ing5-antibody-cab7288ko-validated__18855__19742.1645806428.jpg?c=1 "Anti-ING5 Antibody (CAB7288)[KO Validated]")
- SKU:
- CAB7288
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
![Anti-ING5 Antibody (CAB7288)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/26177/26025/anti-ing5-antibody-cab7288ko-validated__18855__19742.1645806428.jpg?c=1&imbypass=on "Anti-ING5 Antibody (CAB7288)[KO Validated]")
Frequently bought together:
Description
| 抗体名: | Anti-ING5 Antibody [KO Validated] |
| 抗体コード: | CAB7288 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ING5 (NP_115705.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ING5 (NP_115705.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MATA MYLE HYLD SIEN LPCE LQRN FQLM RELD QRTE DKKA EIDI LAAE YIST VKTL SPDQ RVER LQKI QNAY SKCK EYSD DKVQ LAMQ TYEM VDKH IRRL DADL ARFE ADLK DKME GSDF ESSG GRGL KKGR GQKE KRGS RGRG RRTS EEDT PKKK KHKG GSEF TDTI LSVH PSDV LDMP VDPN EPTY CLCH QVSY GEMI GCDN PDCP IEWF HFAC VDLT |
| 遺伝子ID: | 84289 |
| Uniprot: | Q8WYH8 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 25kDa/27kDa |
| 観察された分子量: | 30KDa |
| 同義語: | ING5, p28ING5 |
| バックグラウンド: | This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' ends results in multiple transcript variants. |
| UniProt Protein Function: | ING5: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Belongs to the ING family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; zinc ion binding; chromatin binding; methylated histone residue binding Biological Process: negative regulation of cell proliferation; establishment and/or maintenance of chromatin architecture; protein amino acid acetylation; transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; DNA replication; negative regulation of growth |
| NCBI Summary: | The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WYH8 |
| NCBI GenInfo Identifier: | 57012960 |
| NCBI Gene ID: | 84289 |
| NCBI Accession: | Q8WYH8.1 |
| UniProt Secondary Accession: | Q8WYH8,Q53NU6, Q57Z54, Q9BS30, A8K1P3, |
| UniProt Related Accession: | Q8WYH8 |
| Molecular Weight: | 240 |
| NCBI Full Name: | Inhibitor of growth protein 5 |
| NCBI Synonym Full Names: | inhibitor of growth family, member 5 |
| NCBI Official Symbol: | ING5 |
| NCBI Official Synonym Symbols: | p28ING5 |
| NCBI Protein Information: | inhibitor of growth protein 5 |
| UniProt Protein Name: | Inhibitor of growth protein 5 |
| UniProt Synonym Protein Names: | p28ING5 |
| Protein Family: | Inhibitor of growth protein |
| UniProt Gene Name: | ING5 |
| UniProt Entry Name: | ING5_HUMAN |
![Anti-ING5 Antibody [KO Validated] (CAB7288)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/h/864/A7288_1__98942.jpg) | Western blot analysis of extracts of 293T cells, using ING5 antibody (CAB7288) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
![Anti-ING5 Antibody [KO Validated] (CAB7288)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/c/096/A7288_2__99429.jpg) | Immunofluorescence analysis of MCF-7 cells using ING5 antibody (CAB7288). Blue: DAPI for nuclear staining. |
View AllClose