Anti-IL36RN Antibody (CAB8205)
- SKU:
- CAB8205
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | IL36RN Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8205 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-155 of human IL36RN (NP_036407.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse spleen, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-155 of human IL36RN (NP_036407.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MVLS GALC FRMK DSAL KVLY LHNN QLLA GGLH AGKV IKGE EISV VPNR WLDA SLSP VILG VQGG SQCL SCGV GQEP TLTL EPVN IMEL YLGA KESK SFTF YRRD MGLT SSFE SAAY PGWF LCTV PEAD QPVR LTQL PENG GWNA PITD FYFQ QCD |
| 遺伝子ID: | 26525 |
| Uniprot: | Q9UBH0 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 16kDa |
| 観察された分子量: | 17kDa |
| 同義語: | IL36RN, FIL1, FIL1(DELTA), FIL1D, IL-36Ra, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, PSORS14 |
| バックグラウンド: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. |
| UniProt Protein Function: | IL1F5: Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL- 1R1), that is present in epithelial barriers and takes part in local inflammatory response. Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP). PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. Belongs to the IL-1 family. |
| UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 2q14 Cellular Component: extracellular space Molecular Function:cytokine activity; interleukin-1 receptor binding; protein binding Biological Process: antifungal humoral response; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of interleukin-17 production Disease: Psoriasis 14, Pustular |
| NCBI Summary: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBH0 |
| NCBI GenInfo Identifier: | 25008600 |
| NCBI Gene ID: | 26525 |
| NCBI Accession: | Q9UBH0.1 |
| UniProt Secondary Accession: | Q9UBH0,Q56AT9, Q7RTZ6, A8K2I4, |
| UniProt Related Accession: | Q9UBH0 |
| Molecular Weight: | 16,962 Da |
| NCBI Full Name: | Interleukin-36 receptor antagonist protein |
| NCBI Synonym Full Names: | interleukin 36 receptor antagonist |
| NCBI Official Symbol: | IL36RN |
| NCBI Official Synonym Symbols: | FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA) |
| NCBI Protein Information: | interleukin-36 receptor antagonist protein |
| UniProt Protein Name: | Interleukin-36 receptor antagonist protein |
| UniProt Synonym Protein Names: | FIL1 delta; IL-1-related protein 3; IL-1RP3; Interleukin-1 HY1; IL-1HY1; Interleukin-1 delta; IL-1 delta; Interleukin-1 family member 5; IL-1F5; Interleukin-1 receptor antagonist homolog 1; IL-1ra homolog 1; Interleukin-1-like protein 1; IL-1L1 |
| Protein Family: | Interleukin-36 receptor antagonist protein |
| UniProt Gene Name: | IL36RN |
| UniProt Entry Name: | I36RA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL36RN antibody (CAB8205) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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