Anti-IL27RA Antibody (CAB8176)
- SKU:
- CAB8176
- Product type:
- Antibody
- Application:
- WB
- Application:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | IL27RA Rabbit Polyclonal Antibody |
抗体コード: | CAB8176 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-283 of human IL27RA (NP_004834.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | MCF7, Mouse liver, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-283 of human IL27RA (NP_004834.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | QGSA GPLQ CYGV GPLG DLNC SWEP LGDL GAPS ELHL QSQK YRSN KTQT VAVA AGRS WVAI PREQ LTMS DKLL VWGT KAGQ PLWP PVFV NLET QMKP NAPR LGPD VDFS EDDP LEAT VHWA PPTW PSHK VLIC QFHY RRCQ EAAW TLLE PELK TIPL TPVE IQDL ELAT GYKV YGRC RMEK EEDL WGEW SPIL SFQT PPSA PKDV WVSG NLCG TPGG EEPL LLWK APGP CVQV SYKV WFWV GGRE LSPE GIT |
遺伝子ID: | 9466 |
Uniprot: | Q6UWB1 |
セルラーロケーション: | Membrane, Single-pass type I membrane protein |
計算された分子量: | 69kDa |
観察された分子量: | 75kDa |
同義語: | IL27RA, CRL1, IL-27RA, IL27R, TCCR, WSX1, zcytor1 |
バックグラウンド: | In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. |
UniProt Protein Function: | IL27RA: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms. Belongs to the type I cytokine receptor family. Type 2 subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:transmembrane receptor activity Biological Process: cell surface receptor linked signal transduction; immune response |
NCBI Summary: | In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q6UWB1 |
NCBI GenInfo Identifier: | 116242518 |
NCBI Gene ID: | 9466 |
NCBI Accession: | Q6UWB1.2 |
UniProt Secondary Accession: | Q6UWB1,O60624, A0N0L1, |
UniProt Related Accession: | Q6UWB1 |
Molecular Weight: | 69,474 Da |
NCBI Full Name: | Interleukin-27 receptor subunit alpha |
NCBI Synonym Full Names: | interleukin 27 receptor subunit alpha |
NCBI Official Symbol: | IL27RA |
NCBI Official Synonym Symbols: | CRL1; TCCR; WSX1; IL27R; IL-27RA; zcytor1 |
NCBI Protein Information: | interleukin-27 receptor subunit alpha |
UniProt Protein Name: | Interleukin-27 receptor subunit alpha |
UniProt Synonym Protein Names: | Cytokine receptor WSX-1; Cytokine receptor-like 1; Type I T-cell cytokine receptor; TCCR; ZcytoR1 |
Protein Family: | Interleukin-27 receptor |
UniProt Gene Name: | IL27RA |
UniProt Entry Name: | I27RA_HUMAN |
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