Anti-IL-1RAPL1 Antibody (CAB3378)
- SKU:
- CAB3378
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | IL1RAPL1 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB3378 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-210 of human IL1RAPL1 (NP_055086.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-431, Mouse brain, Mouse heart, Rat brain, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-210 of human IL1RAPL1 (NP_055086.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SISL TVGE NDTG LCYN SKMK YFEK AELS KSKE ISCR DIED FLLP TREP EILW YKEC RTKT WRPS IVFK RDTL LIRE VRED D |
| 遺伝子ID: | 11141 |
| Uniprot: | Q9NZN1 |
| セルラーロケーション: | Cell membrane, Cell projection, Cytoplasm, Single-pass type I membrane protein, axon, dendrite |
| 計算された分子量: | 79kDa |
| 観察された分子量: | 90kDa |
| 同義語: | IL1RAPL1, IL1R8, IL1RAPL, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2 |
| バックグラウンド: | The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. |
| UniProt Protein Function: | IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: Xp22.1-p21.3 Cellular Component: postsynaptic membrane; cell surface; axon; cytoplasm; dendrite; plasma membrane; integral to membrane Molecular Function:voltage-gated calcium channel activity; protein binding; interleukin-1 binding; receptor binding Biological Process: heterophilic cell adhesion; neuron differentiation; negative regulation of exocytosis; positive regulation of dendrite morphogenesis; signal transduction Disease: Mental Retardation, X-linked 21 |
| NCBI Summary: | The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017] |
| UniProt Code: | Q9NZN1 |
| NCBI GenInfo Identifier: | 34222654 |
| NCBI Gene ID: | 11141 |
| NCBI Accession: | Q9NZN1.2 |
| UniProt Related Accession: | Q9NZN1 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-1 receptor accessory protein-like 1 |
| NCBI Synonym Full Names: | interleukin 1 receptor accessory protein like 1 |
| NCBI Official Symbol: | IL1RAPL1 |
| NCBI Official Synonym Symbols: | IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1 |
| NCBI Protein Information: | interleukin-1 receptor accessory protein-like 1 |
| UniProt Protein Name: | Interleukin-1 receptor accessory protein-like 1 |
| UniProt Synonym Protein Names: | Oligophrenin-4; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; X-linked interleukin-1 receptor accessory protein-like 1 |
| UniProt Gene Name: | IL1RAPL1 |
| UniProt Entry Name: | IRPL1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL1RAPL1 antibody (CAB3378) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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