| バックグラウンド: | The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. |
| UniProt Protein Function: | Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation. |
| NCBI Summary: | The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96PD4 |
| NCBI GenInfo Identifier: | 239938888 |
| NCBI Gene ID: | 112744 |
| NCBI Accession: | Q96PD4.3 |
| UniProt Secondary Accession: | Q96PD4,Q6NSI0, Q7Z6P4, Q96PI8, Q9NUE6, |
| UniProt Related Accession: | Q96PD4 |
| Molecular Weight: | 18,045 Da |
| NCBI Full Name: | Interleukin-17F |
| NCBI Synonym Full Names: | interleukin 17F |
| NCBI Official Symbol: | IL17F |
| NCBI Official Synonym Symbols: | ML1; ML-1; CANDF6; IL-17F |
| NCBI Protein Information: | interleukin-17F |
| UniProt Protein Name: | Interleukin-17F |
| UniProt Synonym Protein Names: | Cytokine ML-1 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL17F |
