Anti-IL-17A Receptor Antibody (CAB5163)
- SKU:
- CAB5163
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-IL-17A Receptor Antibody |
抗体コード: | CAB5163 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human IL17A Receptor |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse lung, Rat kidney |
免疫原: | A synthesized peptide derived from human IL17A Receptor |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 23765 |
Uniprot: | Q96F46 |
セルラーロケーション: | |
計算された分子量: | 160kDa |
観察された分子量: | 120KDa |
同義語: | CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R |
バックグラウンド: | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] |
UniProt Protein Function: | Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971). |
NCBI Summary: | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] |
UniProt Code: | Q96F46 |
NCBI GenInfo Identifier: | 116242517 |
NCBI Gene ID: | 23765 |
NCBI Accession: | Q96F46.2 |
UniProt Secondary Accession: | Q96F46,O43844, Q20WK1, |
UniProt Related Accession: | Q96F46 |
Molecular Weight: | 92,153 Da |
NCBI Full Name: | Interleukin-17 receptor A |
NCBI Synonym Full Names: | interleukin 17 receptor A |
NCBI Official Symbol: | IL17RA |
NCBI Official Synonym Symbols: | CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R |
NCBI Protein Information: | interleukin-17 receptor A |
UniProt Protein Name: | Interleukin-17 receptor A |
UniProt Synonym Protein Names: | CDw217; CD_antigen: CD217 |
Protein Family: | Interleukin-17 receptor |
UniProt Gene Name: | IL17RA |
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