Anti-IL-11RA Antibody (CAB6627)
- SKU:
- CAB6627
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | IL11RA Rabbit Polyclonal Antibody |
| 抗体コード: | CAB6627 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human IL11RA (NP_001136256.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse kidney, Mouse heart, Mouse skeletal muscle, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human IL11RA (NP_001136256.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | WGPP GVQY GQPG RSVK LCCP GVTA GDPV SWFR DGEP KLLQ GPDS GLGH ELVL AQAD STDE GTYI CQTL DGAL GGTV TLQL GYPP ARPV VSCQ AADY ENFS CTWS PSQI SGLP TRYL TSYR KKTV LGAD SQRR SPST GPWP CPQD PLGA ARCV VHGA EFWS QYRI NVTE VNPL GAST RLLD VSLQ SILR PDPP QGLR VESV PGYP RRLR ASWT YPAS WPCQ PHFL LKFR LQYR PAQH PAWS TVEP AGLE EVIT DAVA GLPH A |
| 遺伝子ID: | 3590 |
| Uniprot: | Q14626 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 41kDa/45kDa |
| 観察された分子量: | 45kDa |
| 同義語: | IL11RA, CRSDA |
| バックグラウンド: | Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Defects in IL11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 9p13 Cellular Component: integral to plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; signal transducer activity; transmembrane receptor activity Biological Process: cytokine and chemokine mediated signaling pathway; signal transduction; developmental process; embryo implantation Disease: Craniosynostosis And Dental Anomalies |
| NCBI Summary: | Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012] |
| UniProt Code: | Q14626 |
| NCBI GenInfo Identifier: | 55976300 |
| NCBI Gene ID: | 3590 |
| NCBI Accession: | Q14626.2 |
| UniProt Secondary Accession: | Q14626,Q16542, Q5VZ80, Q7KYJ7, |
| UniProt Related Accession: | Q14626 |
| Molecular Weight: | 422 |
| NCBI Full Name: | Interleukin-11 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 11 receptor, alpha |
| NCBI Official Symbol: | IL11RA |
| NCBI Official Synonym Symbols: | CRSDA |
| NCBI Protein Information: | interleukin-11 receptor subunit alpha; IL-11R subunit alpha; IL-11 receptor subunit alpha; interleukin-11 receptor alpha chain |
| UniProt Protein Name: | Interleukin-11 receptor subunit alpha |
| Protein Family: | Interleukin-11 receptor |
| UniProt Gene Name: | IL11RA |
| UniProt Entry Name: | I11RA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL11RA Antibody (CAB6627) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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