Anti-IKZF3 Antibody (CAB7287)
- SKU:
- CAB7287
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-IKZF3 Antibody |
| 抗体コード: | CAB7287 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-450 of human IKZF3 (NP_036613.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | BT-474, Mouse thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-450 of human IKZF3 (NP_036613.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | HCFD VNYN SSYM YEKE SELI QTRM MDQA INNA ISYL GAEA LRPL VQTP PAPT SEMV PVIS SMYP IALT RAEM SNGA PQEL EKKS IHLP EKSV PSER GLSP NNSG HDST DTDS NHEE RQNH IYQQ NHMV LSRA RNGM PLLK EVPR SYEL LKPP PICP RDSV KVIN KEGE VMD |
| 遺伝子ID: | 22806 |
| Uniprot: | Q9UKT9 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 29-58kDa |
| 観察された分子量: | 58kDa |
| 同義語: | IKZF3, AIO, AIOLOS, ZNFN1A3 |
| バックグラウンド: | This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. |
| UniProt Protein Function: | Aiolos: a transcription factor of the ikaros C2H2-type zinc-finger protein family. Plays an important role in the regulation of lymphocyte differentiation. Deletions in Aiolos have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 17q21 Cellular Component: cytoplasm; plasma membrane; nucleus Molecular Function:protein binding; protein homodimerization activity; protein heterodimerization activity; sequence-specific DNA binding; metal ion binding; transcription factor activity Biological Process: regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; B cell activation; transcription, DNA-dependent; regulation of lymphocyte differentiation; regulation of B cell differentiation; regulation of B cell proliferation; mesoderm development |
| NCBI Summary: | This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q9UKT9 |
| NCBI GenInfo Identifier: | 212276437 |
| NCBI Gene ID: | 22806 |
| NCBI Accession: | Q9UKT9.2 |
| UniProt Secondary Accession: | Q9UKT9,Q69BL6, Q69BL7, Q69BL8, Q69BL9, Q69BM0, Q69BM1 Q69BM2, Q69BM3, Q69BM5, Q8N574, B4DVV5, |
| UniProt Related Accession: | Q9UKT9 |
| Molecular Weight: | 509 |
| NCBI Full Name: | Zinc finger protein Aiolos |
| NCBI Synonym Full Names: | IKAROS family zinc finger 3 (Aiolos) |
| NCBI Official Symbol: | IKZF3 |
| NCBI Official Synonym Symbols: | AIO; AIOLOS; ZNFN1A3 |
| NCBI Protein Information: | zinc finger protein Aiolos; zinc finger DNA binding protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos) |
| UniProt Protein Name: | Zinc finger protein Aiolos |
| UniProt Synonym Protein Names: | Ikaros family zinc finger protein 3 |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | IKZF3 |
| UniProt Entry Name: | IKZF3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IKZF3 Antibody (CAB7287) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of MCF-7 cells using IKZF3 antibody (CAB7287). Blue: DAPI for nuclear staining. |
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