Anti-IKBKAP Antibody (CAB10127)
- SKU:
- CAB10127
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-IKBKAP Antibody |
抗体コード: | CAB10127 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1093-1332 of human IKBKAP (NP_003631.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:1000 - 1:4000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, HepG2, U-251MG, HL-60, Mouse liver, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1093-1332 of human IKBKAP (NP_003631.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LRLV YKYN RLDI IETN VKPS ILEA QKNY MAFL DSQT ATFS RHKK RLLV VREL KEQA QQAG LDDE VPHG QESD LFSE TSSV VSGS EMSG KYSH SNSR ISAR SSKN RRKA ERKK HSLK EGSP LEDL ALLE ALSE VVQN TENL KDEV YHIL KVLF LFEF DEQG RELQ KAFE DTLQ LMER SLPE IWTL TYQQ NSAT PVLG PNST ANSI MASY QQQK TSVP VLDA ELFI PPKI NRRT QWKL SLLD |
遺伝子ID: | 8518 |
Uniprot: | O95163 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 150kDa |
観察された分子量: | 150kDa |
同義語: | IKBKAP, DYS, ELP1, FD, IKAP, IKI3, TOT1 |
バックグラウンド: | The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. |
UniProt Protein Function: | IKBKAP: May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3. Belongs to the ELP1/IKA1 family. |
UniProt Protein Details: | Protein type:Transcription regulation; Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 9q31 Cellular Component: transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; nucleolus; histone acetyltransferase complex Molecular Function:protein binding; signal transducer activity; phosphorylase kinase regulator activity Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; RNA elongation from RNA polymerase II promoter; immune response; protein complex assembly; signal transduction; regulation of protein kinase activity; protein amino acid phosphorylation; positive regulation of cell migration Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iii |
NCBI Summary: | The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95163 |
NCBI GenInfo Identifier: | 3757822 |
NCBI Gene ID: | 8518 |
NCBI Accession: | AAC64258.1 |
UniProt Secondary Accession: | O95163,Q5JSV2, Q9H327, Q9UG87, |
UniProt Related Accession: | O95163 |
Molecular Weight: | 150,254 Da |
NCBI Full Name: | IkappaB kinase complex associated protein |
NCBI Synonym Full Names: | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein |
NCBI Official Symbol: | IKBKAP |
NCBI Official Synonym Symbols: | FD; DYS; ELP1; IKAP; IKI3; TOT1 |
NCBI Protein Information: | elongator complex protein 1 |
UniProt Protein Name: | Elongator complex protein 1 |
UniProt Synonym Protein Names: | IkappaB kinase complex-associated protein; IKK complex-associated protein; p150 |
UniProt Gene Name: | IKBKAP |
UniProt Entry Name: | ELP1_HUMAN |