Anti-IGLL1 Antibody (CAB20257)

(No reviews yet) Write a Review
SKU:
CAB20257
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
IGO
Synonyms:
14.1
Synonyms:
AGM2
Synonyms:
IGL1
Synonyms:
IGL5
Synonyms:
IGLL
Synonyms:
IGVPB
Synonyms:
CD179b
Synonyms:
VPREB2
Synonyms:
IGLJ14.1
€0.00
Frequently bought together:

Description

抗体名:IGLL1 Rabbit pAb
抗体コード:CAB20257
サイズ:50uL, 100uL
同義語:IGO, 14.1, AGM2, IGL1, IGL5, IGLL, IGVPB, CD179b, VPREB2, IGLJ14.1
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:Recombinant protein of human IGLL1.
申し込み:WB
推奨される希釈:WB 1:1000 - 1:2000
反応性:Human
免疫原:Recombinant protein of human IGLL1.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:3543
Uniprot:P15814
計算された分子量:23kDa
観察された分子量:Refer to figures
UniProt Protein Function:IGLL1: Critical for B-cell development. Defects in IGLL1 are the cause of agammaglobulinemia type 2 (AGM2). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 22q11.23 Cellular Component: external side of plasma membrane; membrane Molecular Function: antigen binding Biological Process: B cell receptor signaling pathway; complement activation, classical pathway; defense response to bacterium; immune response; innate immune response; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of B cell activation Disease: Agammaglobulinemia 2, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P15814
NCBI GenInfo Identifier:123944
NCBI Gene ID:3543
NCBI Accession:P15814.1
UniProt Secondary Accession:P15814,Q0P681
UniProt Related Accession:P15814
Molecular Weight:8,574 Da
NCBI Full Name:Immunoglobulin lambda-like polypeptide 1
NCBI Synonym Full Names:immunoglobulin lambda like polypeptide 1
NCBI Official Symbol:IGLL1  
NCBI Official Synonym Symbols:IGO; 14.1; AGM2; IGL1; IGL5; IGLL; IGVPB; CD179b; VPREB2; IGLJ14.1  
NCBI Protein Information:immunoglobulin lambda-like polypeptide 1
UniProt Protein Name:Immunoglobulin lambda-like polypeptide 1
UniProt Synonym Protein Names:CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD_antigen: CD179b
Protein Family:Ig lambda chain C region
UniProt Gene Name:IGLL1  
UniProt Entry Name:IGLL1_HUMAN
View AllClose

View AllClose

Related Products