Anti-IGHD Antibody (CAB19708)
- SKU:
- CAB19708
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | IGHD Rabbit mAb |
| 抗体コード: | CAB19708 |
| サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human IGHD |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | Human plasma |
| 免疫原: | A synthesized peptide derived from human IGHD |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3495 |
| Uniprot: | P01880 |
| 計算された分子量: | 84kDa |
| 観察された分子量: | 55KDa |
| UniProt Protein Function: | IGHD: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 14q32.33 Cellular Component: integral to membrane; plasma membrane Molecular Function:antigen binding Biological Process: immune response |
| UniProt Code: | P01880 |
| NCBI GenInfo Identifier: | 193806360 |
| NCBI Gene ID: | 3495 |
| NCBI Accession: | P01880.2 |
| UniProt Secondary Accession: | P01880,Q6P4I8, Q8WU38, |
| UniProt Related Accession: | P01880 |
| Molecular Weight: | 47,401 Da |
| NCBI Full Name: | Ig delta chain C region, partial |
| NCBI Synonym Full Names: | immunoglobulin heavy constant delta |
| NCBI Official Symbol: | IGHD |
| UniProt Protein Name: | Ig delta chain C region |
| UniProt Gene Name: | IGHD |
| UniProt Entry Name: | IGHD_HUMAN |
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