Anti-IGFBP7 Antibody (CAB2982)
- SKU:
- CAB2982
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-IGFBP7 Antibody |
| 抗体コード: | CAB2982 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human IGFBP7 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SW480, K-562, 293T, HepG2, U-87MG, Mouse spleen |
| 免疫原: | A synthetic peptide of human IGFBP7 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3490 |
| Uniprot: | Q16270 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 28kDa/29kDa |
| 観察された分子量: | 37kDa |
| 同義語: | IGFBP7, AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF |
| バックグラウンド: | This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). |
| UniProt Protein Function: | IGFBP7: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS). RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cell adhesion; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 4q12 Cellular Component: extracellular matrix; extracellular space; extracellular region Molecular Function:insulin-like growth factor binding; protein binding Biological Process: negative regulation of cell proliferation; response to retinoic acid; response to cortisol stimulus; response to heat; regulation of steroid biosynthetic process; regulation of cell growth; cell adhesion; inner ear development; embryo implantation; cellular response to hormone stimulus Disease: Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis |
| NCBI Summary: | This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q16270 |
| NCBI GenInfo Identifier: | 23396609 |
| NCBI Gene ID: | 3490 |
| NCBI Accession: | Q16270.1 |
| UniProt Related Accession: | Q16270 |
| Molecular Weight: | |
| NCBI Full Name: | Insulin-like growth factor-binding protein 7 |
| NCBI Synonym Full Names: | insulin like growth factor binding protein 7 |
| NCBI Official Symbol: | IGFBP7 |
| NCBI Official Synonym Symbols: | AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1 |
| NCBI Protein Information: | insulin-like growth factor-binding protein 7 |
| UniProt Protein Name: | Insulin-like growth factor-binding protein 7 |
| UniProt Synonym Protein Names: | IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF |
| Protein Family: | Insulin-like growth factor-binding protein |
| UniProt Gene Name: | IGFBP7 |
| UniProt Entry Name: | IBP7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IGFBP7 antibody (CAB2982) at 1:400 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
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