Anti-IGFBP4 Antibody (CAB15068)

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SKU:
CAB15068
Product type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

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抗体名:Anti-IGFBP4 Antibody
抗体コード:CAB15068
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 178-258 of human IGFBP4 (NP_001543.2).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Mouse, Rat
ポジティブサンプル:mouse brain, mouse kidney, rat liver
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 178-258 of human IGFBP4 (NP_001543.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:LHRA LERL AASQ SRTH EDLY IIPI PNCD RNGN FHPK QCHP ALDG QRGK CWCV DRKT GVKL PGGL EPKG ELDC HQLA DSFR E
遺伝子ID:3487
Uniprot:P22692
セルラーロケーション:Secreted
計算された分子量:17kDa/27kDa
観察された分子量:28kDa
同義語:IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4
バックグラウンド:This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
UniProt Protein Function:IGFBP4: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: extracellular region; extracellular space

Molecular Function:insulin-like growth factor I binding; insulin-like growth factor II binding; receptor binding

Biological Process: cell proliferation; cellular protein metabolic process; DNA metabolic process; regulation of insulin-like growth factor receptor signaling pathway; signal transduction; skeletal development

NCBI Summary:This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
UniProt Code:P22692
NCBI GenInfo Identifier:124065
NCBI Gene ID:3487
NCBI Accession:P22692.2
UniProt Secondary Accession:P22692,Q5U012, Q9UCL6, A0N9W2, B4E351,
UniProt Related Accession:P22692
Molecular Weight:17,635 Da
NCBI Full Name:Insulin-like growth factor-binding protein 4
NCBI Synonym Full Names:insulin like growth factor binding protein 4
NCBI Official Symbol:IGFBP4  
NCBI Official Synonym Symbols:BP-4; IBP4; IGFBP-4; HT29-IGFBP  
NCBI Protein Information:insulin-like growth factor-binding protein 4
UniProt Protein Name:Insulin-like growth factor-binding protein 4
Protein Family:Insulin-like growth factor-binding protein
UniProt Gene Name:IGFBP4  
UniProt Entry Name:IBP4_HUMAN
Anti-IGFBP4 Antibody (CAB15068)Western blot analysis of extracts of various cell lines, using IGFBP4 antibody (CAB15068) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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