Anti-IGFBP2 Antibody (CAB0403)
- SKU:
- CAB0403
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| 抗体名: | Anti-IGFBP2 Antibody |
| 抗体コード: | CAB0403 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human IGFBP2 (NP_000588.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | LO2, HeLa, SW480 |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human IGFBP2 (NP_000588.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ACGV YTPR CGQG LRCY PHPG SELP LQAL VMGE GTCE KRRD AEYG ASPE QVAD NGDD HSEG GLVE NHVD STMN MLGG GGSA GRKP LKSG MKEL AVFR EKVT E |
| 遺伝子ID: | 3485 |
| Uniprot: | P18065 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 34kDa |
| 観察された分子量: | 37kDa |
| 同義語: | IGFBP2, IBP2, IGF-BP53 |
| バックグラウンド: | The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. |
| UniProt Protein Function: | IGFBP2: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q35 Cellular Component: extracellular space; apical plasma membrane; extracellular region; cytoplasmic vesicle Molecular Function:protein binding; insulin-like growth factor I binding; insulin-like growth factor II binding Biological Process: response to drug; regulation of insulin-like growth factor receptor signaling pathway; response to retinoic acid; response to lithium ion; response to glucocorticoid stimulus; female pregnancy; positive regulation of activated T cell proliferation; signal transduction; response to estradiol stimulus; cellular response to hormone stimulus; cellular protein metabolic process; response to mechanical stimulus; regulation of cell growth; response to nutrient; aging |
| UniProt Code: | P18065 |
| NCBI GenInfo Identifier: | 290457647 |
| NCBI Gene ID: | 3485 |
| NCBI Accession: | P18065.2 |
| UniProt Secondary Accession: | P18065,Q14619, Q9UCL3, |
| UniProt Related Accession: | P18065 |
| Molecular Weight: | 34,814 Da |
| NCBI Full Name: | Insulin-like growth factor-binding protein 2 |
| NCBI Synonym Full Names: | insulin-like growth factor binding protein 2, 36kDa |
| NCBI Official Symbol: | IGFBP2 |
| NCBI Official Synonym Symbols: | IBP2; IGF-BP53 |
| NCBI Protein Information: | insulin-like growth factor-binding protein 2; IBP-2; IGFBP-2; IGF-binding protein 2 |
| UniProt Protein Name: | Insulin-like growth factor-binding protein 2 |
| Protein Family: | Insulin-like growth factor-binding protein |
| UniProt Gene Name: | IGFBP2 |
| UniProt Entry Name: | IBP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IGFBP2 antibody (CAB0403) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |