Anti-IGFBP1 Antibody (CAB2981)
- SKU:
- CAB2981
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-IGFBP1 Antibody |
| 抗体コード: | CAB2981 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-259 of human IGFBP1 (NP_000587.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | H460, Mouse kidney, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-259 of human IGFBP1 (NP_000587.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | APWQ CAPC SAEK LALC PPVS ASCS EVTR SAGC GCCP MCAL PLGA ACGV ATAR CARG LSCR ALPG EQQP LHAL TRGQ GACV QESD ASAP HAAE AGSP ESPE STEI TEEE LLDN FHLM APSE EDHS ILWD AIST YDGS KALH VTNI KKWK EPCR IELY RVVE SLAK AQET SGEE ISKF YLPN CNKN GFYH SRQC ETSM DGEA GLCW CVYP WNGK RIPG SPEI RGDP NCQI YFNV QN |
| 遺伝子ID: | 3484 |
| Uniprot: | P08833 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 27kDa |
| 観察された分子量: | 37kDa |
| 同義語: | IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1 |
| バックグラウンド: | This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. |
| UniProt Protein Function: | IGFBP1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 7p12.3 Cellular Component: extracellular region; extracellular space Molecular Function:insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding Biological Process: cellular protein metabolic process; insulin receptor signaling pathway; positive regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway; signal transduction; tissue regeneration; unfolded protein response |
| NCBI Summary: | This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08833 |
| NCBI GenInfo Identifier: | 124055 |
| NCBI Gene ID: | 3484 |
| NCBI Accession: | P08833.1 |
| UniProt Secondary Accession: | P08833,Q8IYP5, A4D2F4, D3DVL9, |
| UniProt Related Accession: | P08833 |
| Molecular Weight: | 27,904 Da |
| NCBI Full Name: | Insulin-like growth factor-binding protein 1 |
| NCBI Synonym Full Names: | insulin like growth factor binding protein 1 |
| NCBI Official Symbol: | IGFBP1 |
| NCBI Official Synonym Symbols: | AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1 |
| NCBI Protein Information: | insulin-like growth factor-binding protein 1 |
| UniProt Protein Name: | Insulin-like growth factor-binding protein 1 |
| UniProt Synonym Protein Names: | Placental protein 12; PP12 |
| Protein Family: | Insulin-like growth factor-binding protein |
| UniProt Gene Name: | IGFBP1 |
| UniProt Entry Name: | IBP1_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using IGFBP1 antibody (CAB2981) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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