Anti-IGF2BP2 Antibody (CAB1774)
- SKU:
- CAB1774
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-IGF2BP2 Antibody |
| 抗体コード: | CAB1774 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-599 of human IGF2BP2 (NP_006539.3). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HT-29, BxPC-3, HeLa, Jurkat, NIH/3T3 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-599 of human IGF2BP2 (NP_006539.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TVEA CASA EIEI MKKL REAF ENDM LAVN QQAN LIPG LNLS ALGI FSTG LSVL SPPA GPRG APPA APYH PFTT HSGY FSSL YPHH QFGP FPHH HSYP EQEI VNLF IPTQ AVGA IIGK KGAH IKQL ARFA GASI KIAP AEGP DVSE RMVI ITGP PEAQ FKAQ GRIF GKLK EENF FNPK EEVK LEAH IRVP SSTA GRVI GKGG KTVN ELQN LTSA EVIV PRDQ TPDE NEEV IVRI IGHF FASQ TAQR KIRE IVQQ VKQQ EQKY PQGV ASQR SK |
| 遺伝子ID: | 10644 |
| Uniprot: | Q9Y6M1 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 54kDa/58kDa/59kDa/61kDa/66kDa |
| 観察された分子量: | 70kDa |
| 同義語: | IGF2BP2, IMP-2, IMP2, VICKZ2 |
| バックグラウンド: | This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. |
| UniProt Protein Function: | IGF2BP2: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs. Belongs to the RRM IMP/VICKZ family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; Translation Chromosomal Location of Human Ortholog: 3q27.2 Cellular Component: cytoskeleton; cytoplasm; nucleus; cytosol Molecular Function:protein binding; mRNA 3'-UTR binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding Biological Process: anatomical structure morphogenesis; mRNA transport; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process Disease: Diabetes Mellitus, Noninsulin-dependent |
| NCBI Summary: | This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014] |
| UniProt Code: | Q9Y6M1 |
| NCBI GenInfo Identifier: | 224471831 |
| NCBI Gene ID: | 10644 |
| NCBI Accession: | Q9Y6M1.2 |
| UniProt Secondary Accession: | Q9Y6M1,A0A4Z0, B3FTN2, B3FTN3, B3FTN4, |
| UniProt Related Accession: | Q9Y6M1 |
| Molecular Weight: | 599 |
| NCBI Full Name: | Insulin-like growth factor 2 mRNA-binding protein 2 |
| NCBI Synonym Full Names: | insulin-like growth factor 2 mRNA binding protein 2 |
| NCBI Official Symbol: | IGF2BP2 |
| NCBI Official Synonym Symbols: | IMP2; IMP-2; VICKZ2 |
| NCBI Protein Information: | insulin-like growth factor 2 mRNA-binding protein 2; VICKZ family member 2; IGF2 mRNA-binding protein 2; IGF-II mRNA-binding protein 2 |
| UniProt Protein Name: | Insulin-like growth factor 2 mRNA-binding protein 2 |
| UniProt Synonym Protein Names: | Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2 |
| Protein Family: | Insulin-like growth factor 2 mRNA-binding protein |
| UniProt Gene Name: | IGF2BP2 |
| UniProt Entry Name: | IF2B2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IGF2BP2 antibody (CAB1774) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of U-2 OS cells using IGF2BP2 antibody (CAB1774) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of rat testis cells using IGF2BP2 antibody (CAB1774) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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