| UniProt Protein Function: | TTC10: Involved in primary cilium biogenesis. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 13q12.1 Cellular Component: centriole; apical part of cell; motile primary cilium; photoreceptor connecting cilium; acrosomal membrane; cilium Molecular Function:kinesin binding Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; epidermis development; regulation of fat cell differentiation; spinal cord dorsal/ventral patterning; palate development; cytoplasmic microtubule organization and biogenesis; cardiac muscle cell differentiation; anterior/posterior pattern formation; spermatid nuclear elongation; protein localization; pancreas development; kidney development; regulation of odontogenesis of dentine-containing teeth; negative regulation of epithelial cell proliferation; smoothened signaling pathway; Notch signaling pathway; organelle organization and biogenesis; forebrain morphogenesis; liver development; inner ear receptor stereocilium organization and biogenesis; telencephalon development; eye development; sperm axoneme assembly; embryonic digit morphogenesis; determination of left/right symmetry; regulation of smoothened signaling pathway |
| NCBI Summary: | This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13099 |
| NCBI GenInfo Identifier: | 206729873 |
| NCBI Gene ID: | 8100 |
| NCBI Accession: | Q13099.2 |
| UniProt Secondary Accession: | Q13099,Q5SZJ6, Q8N719, A2A491, B4DUS2, |
| UniProt Related Accession: | Q13099 |
| Molecular Weight: | 833 |
| NCBI Full Name: | Intraflagellar transport protein 88 homolog |
| NCBI Synonym Full Names: | intraflagellar transport 88 |
| NCBI Official Symbol: | IFT88 |
| NCBI Official Synonym Symbols: | DAF19; TG737; TTC10; hTg737; D13S1056E |
| NCBI Protein Information: | intraflagellar transport protein 88 homolog; polaris homolog; TPR repeat protein 10; tetratricopeptide repeat domain 10; intraflagellar transport 88 homolog; tetratricopeptide repeat protein 10; recessive polycystic kidney disease protein Tg737 homolog; probe hTg737 (polycystic kidney disease, autosomal recessive) |
| UniProt Protein Name: | Intraflagellar transport protein 88 homolog |
| UniProt Synonym Protein Names: | Recessive polycystic kidney disease protein Tg737 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10 |
| Protein Family: | Intraflagellar transport protein |
| UniProt Gene Name: | IFT88 |
| UniProt Entry Name: | IFT88_HUMAN |
