Anti-IFNL3 Antibody (CAB12908)
- SKU:
- CAB12908
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-IFNL3 Antibody |
| 抗体コード: | CAB12908 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human IFNL3 (NP_742151.2). |
| 申し込み: | IHC IF |
| 推奨希釈: | IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human IFNL3 (NP_742151.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VPVA RLRG ALPD ARGC HIAQ FKSL SPQE LQAF KRAK DALE ESLL LKDC KCRS RLFP RTWD LRQL QVRE RPVA LEAE LALT LKVL EATA DTDP ALGD VLDQ PLHT LHHI LSQL RACI QPQP TAGP RTRG RLHH WLHR LQEA PKKE SPGC LEAS VTFN LFRL LTRD LNCV ASGD LCV |
| 遺伝子ID: | 282617 |
| Uniprot: | Q8IZI9 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 21kDa |
| 観察された分子量: |
| 同義語: | IFNL3, IFN-lambda-3, IFN-lambda-4, IL-28B, IL-28C, IL28B, IL28C |
| バックグラウンド: | This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). |
| UniProt Protein Function: | IL-28B: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.13 Cellular Component: extracellular space Molecular Function:cytokine activity Biological Process: positive regulation of immune response; negative regulation of viral genome replication; JAK-STAT cascade; defense response to virus Disease: Hepatitis C Virus, Susceptibility To |
| NCBI Summary: | This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IZI9 |
| NCBI GenInfo Identifier: | 300669648 |
| NCBI Gene ID: | 282617 |
| NCBI Accession: | Q8IZI9.2 |
| UniProt Secondary Accession: | Q8IZI9,Q6VN56, Q7Z4J3, Q8IWL6, A2BDE1, |
| UniProt Related Accession: | Q8IZI9 |
| Molecular Weight: | 196 |
| NCBI Full Name: | Interferon lambda-3 |
| NCBI Synonym Full Names: | interferon, lambda 3 |
| NCBI Official Symbol: | IFNL3 |
| NCBI Official Synonym Symbols: | IL28B; IL28C; IL-28B |
| NCBI Protein Information: | interferon lambda-3; IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28B; interleukin-28C; cytokine Zcyto22; interferon lambda-4; interferon, lambda 4; interleukin 28B (interferon, lambda 3) |
| UniProt Protein Name: | Interferon lambda-3 |
| UniProt Synonym Protein Names: | Cytokine Zcyto22; Interleukin-28B; IL-28B; Interleukin-28C; IL-28C |
| Protein Family: | Interferon |
| UniProt Gene Name: | IFNL3 |
| UniProt Entry Name: | IFNL3_HUMAN |
 | Immunohistochemistry of paraffin-embedded rat brain using IFNL3 antibody (CAB12908) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using IFNL3 antibody (CAB12908) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using IFNL3 antibody (CAB12908) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using IFNL3 antibody (CAB12908) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using IFNL3 antibody (CAB12908) at dilution of 1:100. Blue: DAPI for nuclear staining. |