Anti-IFITM3 Antibody (CAB13070)[KO Validated]

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SKU:
CAB13070
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
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Description

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抗体名:Anti-IFITM3 Antibody [KO Validated]
抗体コード:CAB13070
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IHC IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-133 of human IFITM3 (NP_066362.2).
申し込み:WB IHC IF
推奨希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-133 of human IFITM3 (NP_066362.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MNHT VQTF FSPV NSGQ PPNY EMLK EEHE VAVL GAPH NPAP PTST VIHI RSET SVPD HVVW SLFN TLFM NPCC LGFI AFAY SVKS RDRK MVGD VTGA QAYA STAK CLNI WALI LGIL MTIL LIVI PVLI FQAY G
遺伝子ID:10410
Uniprot:Q01628
セルラーロケーション:Cell membrane, Late endosome membrane, Lysosome membrane, Single-pass type II membrane protein
計算された分子量:14kDa
観察された分子量:15kDa
同義語:IFITM3, 1-8U, DSPA2b, IP15
バックグラウンド:The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined.
UniProt Protein Function:IFITM3: IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Interacts with SPP1; the interaction reduces OPN expression. By IFN-alpha and IFNG/IFN-gamma. Belongs to the CD225/Dispanin family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: lysosomal membrane; late endosome membrane; integral to membrane; plasma membrane

Molecular Function:protein binding

Biological Process: negative regulation of viral transcription; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; response to virus; cytokine and chemokine mediated signaling pathway; immune response; defense response to virus

Disease: Influenza, Severe, Susceptibility To

NCBI Summary:The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]
UniProt Code:Q01628
NCBI GenInfo Identifier:20178301
NCBI Gene ID:10410
NCBI Accession:Q01628.2
UniProt Secondary Accession:Q01628,Q53Y76, Q96HK8, Q96J15,
UniProt Related Accession:Q01628
Molecular Weight:133
NCBI Full Name:Interferon-induced transmembrane protein 3
NCBI Synonym Full Names:interferon induced transmembrane protein 3
NCBI Official Symbol:IFITM3  
NCBI Official Synonym Symbols:1-8U; IP15; DSPA2b  
NCBI Protein Information:interferon-induced transmembrane protein 3; dispanin subfamily A member 2b; interferon-inducible protein 1-8U
UniProt Protein Name:Interferon-induced transmembrane protein 3
UniProt Synonym Protein Names:Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U
UniProt Gene Name:IFITM3  
UniProt Entry Name:IFM3_HUMAN
Anti-IFITM3 Antibody [KO Validated] (CAB13070)Western blot analysis of extracts of HeLa cells, using IFITM3 antibody (CAB13070) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-IFITM3 Antibody [KO Validated] (CAB13070)Western blot analysis of extracts from normal (control) and IFITM3 knockout (KO) HeLa cells, using IFITM3 antibody (CAB13070) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-IFITM3 Antibody [KO Validated] (CAB13070)Immunohistochemistry of paraffin-embedded Human colon carcinoma using [KO Validated] IFITM3 Rabbit pAb (CAB13070) at dilution of 1:100 (40x lens).
Anti-IFITM3 Antibody [KO Validated] (CAB13070)Immunofluorescence analysis of C6 cells using [KO] IFITM3 antibody (CAB13070) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-IFITM3 Antibody [KO Validated] (CAB13070)Immunofluorescence analysis of L929 cells using [KO] IFITM3 antibody (CAB13070) at dilution of 1:100. Blue: DAPI for nuclear staining.
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